摘要急性脑出血患者在发病初期,多伴有应激性高血糖的发生。高血糖状态可以导致患者病死率增加,van den Berghe等[1]于2001年提出了强化胰岛素治疗能降低外科重症监护室（ICU）患者的病死率。但随后的研究又指出,严格控制血糖并无益处,相反,可能因低血糖而造成患者的病死率增加。目前更多的研究人员关注血糖的波动性,其中以血糖不稳定指数（GLI）的研究最为热门。
1Van den Berghe G,Wouters P,Weekers F, et al. Intensive in- sulin therapy in critically ill patients[J]. N Engl Med, 2001, 345(19) .. 1359-1367.
2Egi M, Bellomo R, Stachowski E, et al. Variability of blood glucose concentration and short-term mortality in critically ill patients[J]. Anesthesiology, 2006,105 ~ 244-252.
3Naeem A. Ali, James M. O Brien Jr, Kathleen Dungan, et al. Glucose variability and mortality inpatients with sepsis[J]. Crit Care Med,2008,36 : 2316-2321.
4Quagliaro L, Piconi L, Assaloni R, et al. Intermittent high glucose enhances apoptosis related to oxidative stress in hu- man umbilical vein endothelial cells: the role of protein kinase C and NAD(P) H-oxidase activationEJ]. Diabetes, 2003,52 (11) :2795-2804.
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