妥洛特罗贴剂联合布地奈德混悬液雾化吸入治疗小儿支气管哮喘急性发作的疗效观察

Evaluation of the clinical efficacy of tulobuterol tape-inhalation of pulmicort in the control of acute asthma in infants and young children

目的观察妥洛特罗贴剂联合吸入布地奈德混悬液雾化吸入治疗小儿支气管哮喘急性发作的临床疗效。方法选取支气管哮喘患儿78例,分为治疗组40例,对照组38例,2组患儿均采用相同的综合性治疗,如抗感染、止咳、平喘、维持水电解质平衡等治疗。治疗组在上述综合治疗基础上加用妥洛特罗贴剂（0.6~3岁,每天0.5mg/贴;3~6岁,每天1.0mg/贴;睡前贴于前胸或后背）,对照组给予盐酸丙卡特罗糖浆（0.2mL/kg,12h1次）口服,疗程为5~7d。结果治疗组喘憋消失时间、肺部哮鸣音消失时间及住院天数均短于对照组,差异有统计学意义（P〈0.05）;治疗组显效率为65%,对照组显效率50%,差异有统计学意义（P〈0.01）;治疗组不良反应发生率为12%,对照组为34%,差异有统计学意义（P〈0.01）。结论妥洛特罗贴剂联合吸入布地奈德混悬液雾化吸入治疗小儿支气管哮喘急性发作的疗效确切,不良反应少,依从性佳。

Objective To evaluate the clinical efficacy of tulobuterol tape-inhalation of pulmicort respules in the control of acute asthma in infants and young children.Methods A total of 78 infants and young children with acute asthma episode were allocated to treatment group（n =40）and controls（n =38）.Two groups of children were using the same comprehensive treatment,such as antibiotics,removing cough,eliminating asthma,and other treatments the balance of water,sodium and other electrolytes.At the same time,the treatment group received also tulobuterol tape（0.5mg/paste,0.6-3years,1.0mg/paste,3-6years,bedtime affixed to the chest or back）,and the control group received procaterol hydrochloride syrup（0.2mL/kg,12h1times）orally.The course was5-7days in two groups.Results The disappearance time of wheezing,lung wheeze and the number of days of hospitalization of treatment group was shorter than those in the control group.The difference was significant（P〈0.05）;the efficiency of treatment group was 65%,the control group was 50%,and the difference was statistically significant（P〈0.01）;Rate of side effect was 12%in the treatment group,and rate of side effect in the control group was 34%.The difference was significant（P〈0.01）.Conclusion Tulobuterol tape-inhalation of pulmicort inhalation therapy in infants and young children with bronchial asthma attacks was of significant efficacy,and the compliance is very good.