氧化锡粒子/石墨烯纳米复合材料真空热还原制备及其在近红外胰腺癌热疗中的应用

Redox Approaches Derived Tin(Ⅳ)Oxide Nanoparticles/Graphene Nanocomposites as the Near-infrared Absorber for Human Prostate Cancer Cells Destruction

利用真空热还原法制备得到氧化锡粒子/石墨烯纳米复合材料(SnO2/GR),该过程中,石墨烯氧化物原料既是氧化锡粒子的有效载体来源,也是新型的活泼氧给体,可同步将零价锡氧化为正四价锡,石墨烯氧化物原料则被还原为石墨烯。利用透射电镜(TEM)、扫描电镜(SEM)、X射线衍射(XRD)和傅里叶变换红外光谱等分别对氧化锡粒子/石墨烯纳米复合材料的形貌和尺寸、结构进行了表征。利用该新型材料在近红外(NIR)激光照射下的强光热转化性能,使相比健康细胞更易受到温度影响的胰腺肿瘤细胞内部产生过高热(Hyperthermia),从而诱导胰腺肿瘤细胞热损伤及细胞凋亡。实验结果表明,在1064nm近红外激光照射下,对照组胰腺肿瘤细胞仍保持较高活性,而实验组的胰腺肿瘤细胞活力则大幅降至5.03%,充分显示了氧化锡粒子/石墨烯纳米复合材料在胰腺肿瘤热疗领域的潜力。

Tin （Ⅳ）oxide nanoparticles/graphene （SnO2/GR）nanocomposites were prepared via vacuum ther-mo treatment of Tin （0）and graphene oxide （GO）.A redox reaction would occur readily in this process,in which the novel oxygen donor：GO could act as the oxidizing agent to oxidize Tin （0）to Tin （Ⅳ）,meanwhile,the graphene pre-cursor：GO would be simultaneously reduced to graphene by Tin （0）readily.The resulted composites were characte-rized by Fourier transform infrared spectrometry,scanning electron microscopy,and X-ray diffraction spectroscopy etc..The novel SnO2/GR nanocomposites could combine both advantages of inorganic metal nanoparticles and gra-phene for near infrared spectroscopy （NIR）light absorption to generate heat,which fosters SnO2/GR a special candi-date for photothermal ablation therapy （PTA）with NIR.Further investigations showed that the SnO2/GR nanocom-posites with NIR features could provide viable option for enhancing the thermal deposition （as it could significantly re-duce the survival rate of cancer cell to 5.03% with the presence of a 1064 nm NIR）and specificity of hyperthermia treatments for elimination of human prostate cancer （PC3）.