阿霉素、柔红霉素对CFU-GM和L-CFU细胞毒作用的比较

COMPARATIVE CYTOTOXICITY OF ADRIAMYCIN AND DAUNORUBICIN ON CFU-GM AND L-CFU IN VITRO

微量液体克隆形成法检测的结果提示,柔红霉素对正常人粒细胞、巨噬细胞克隆形成细胞的细胞毒作用是阿霉素的1.98倍(24小时作用法)至2.15倍(168小时作用法),其TDI(Time-schedule Dependence Index)均在100左右。柔红霉素对急非淋患者急性非淋巴细胞白血病细胞克隆形成细胞的细胞毒作用是阿霉素的4.74倍。柔红霉素的平均敏感指数(MSI=2.01±0.53)略大于阿霉素(MSI=1.65±0.49),从理论上解释了柔红霉素多用于治疗急性白血病,阿霉素多用于治疗实体瘤。

The cytotoxic effect of adriamycin and daunorubicin on normal human CFU-GM (colony-forming cell of granulocytes and macrophages)and patients with acute nonlymphocytic leukemia L-CFU (leukemic colony-forming cells) was investigated in a rnicroH uid clonogenic assay in vitro. Against CFU-GM, daunorubicin was 1.98 times (24h exposure method)……2.15 times (168h exposure method) as potent as adrinm vein, their TDI (time-schedule dependence index) were 100 or so. Against L-CFU, daunorubicin. was 4.74 times as potent as adriamycin. The mean sensitivity index of daunorubicin (MSI = 2.01 ±0.53)was slightly larger than that of adriamycin (MSI= 1.65±0.49). It explain why daunorubicin was mainly used for treating acute leukemia while adriamycin for solid tumors.