正交试验优化橙皮苷-镧金属配合物合成工艺研究

Optimization for Synthesis of Hesperidin- Lanthanum Complex by Orthogonal Eexpriment Design

以橙皮苷和氯化镧配合物为原料合成橙皮苷-镧配合物。以产率为考察指标,通过单因素和L9(34)正交试验设计确定了合成橙皮苷-镧配合物的最佳反应条件。结果表明,各因素影响次序橙皮苷用量(B)>反应p H(A)>反应温度(C)>反应时间(D),最优组合为B2A2C2D2,即橙皮苷与氯化镧用量比为2∶1,反应p H8.5,反应温度45℃,反应时间45 min,此条件下配合物产率达58.43%。

Using hesperidin and Lathanum as raw material,hesperidin- La complex was synthesized. With yield ration of hesperidin- La complex as index,the best reaction condition was studied through single factor and orthogonal test of L9（ 3^4）. The primary and secondary factor order was the volumn of hesperidin reaction p H reaction temperature reaction time. The best synthesized condition was reaction for 45 min at 45 ℃ with p H 8. 5 and the ration of hesperidin to Lanthnum 2∶ 1. The yield rate of hesperidin- La complex reached 58. 43%.