住院精神分裂症患者服药态度改善情况及影响因素研究

Inprovement of drug attitude and its influencing factors among schizophrenia inpatients

目的：探讨住院精神分裂症患者的服药态度改善情况及其影响因素。方法使用服药态度问卷（ DAI）及精神病患者生活质量量表（ SQLS）对185例住院精神分裂症患者在入院时及出院前分别评估其服药态度及生活质量,了解患者住院期间服药态度及生活质量的改善情况；将DAI、SQLS出入院分数差值与人口学资料进行Spearmen相关性分析和回归分析。结果185例患者出院前SQLS评分较入院时下降,其中社会心理维度为（28.7±17.0）分、动力精力维度为（44.8±14.5）分、症状不良反应维度为（19.2±18.7）分；而DAI分数较入院时升高为（3.5±4.6）分；差异均有统计学意义（ t值分别为-5.831,-12.112,-7.373,9.875；P〈0.01）。相关性分析显示性别、SQLS各维度改善程度与DAI改善程度相关；线性回归分析显示住院期间患者的SQLS动力精力及症状不良反应改善程度影响DAI的改善程度（P〈0.05）。结论精神分裂症患者住院期间生活质量的改善程度对服药态度改善有影响,尤其是动力精力及症状不良反应改善程度越高,服药态度改善越好。

Objective To discuss the improvement of drug attitude and its influence factors in Schizophrenia inpatients. Methods A total of 185 schizophrenic inpatients were assessed the quality of life and drug attitude, and improvement of them at their admission and before their discharge by life satisfactions rating scales （ SQLS ） and drug attitude inventory （ DAI ） respectively. The Spearman correlation analysis and regression analysis were used to analyze the relationship among the differential value of DAI and SQLS, and demographic data. Results The SOLS scores of all patients dropped down before discharge comparing with scores of admission, in which social psychological dimension was （ 28. 7 ± 17. 0 ） score, dynamic energy dimension （44. 8 ± 14. 5） score, side effect symptom dimension （19. 2 ± 18. 7）; the score of DAI increase to （3. 5 ± 4. 6） （t = -5. 831, -12. 112, -7. 373, 9. 875;P 〈0. 01）. The correlation analysis presented gender, each dimension of SQLS improvement had bound with DAI improvement; liner regression analysis revealed that the improvement of dynamic energy and side effects symptom impacted on the improvement （ P〈0. 05）. Conclusions The improvement of quality of life in schizophrenic inpatients influences the improvement of attitude to taking medication, especially the more improvement of dynamic energy level and side effects symptom. The more quality of life improves, the more improvement of taking medication attitude.