吉西他滨联合奈达铂化疗治疗50例鼻咽癌肺转移的临床疗效分析

Clinical Effect Analysis of Gemcitabine Combined with Nedaplatin Chemotherapy on Treating 50 Cases of Lung Metastases Transform Nasopharyngeal Carcinoma

目的：观察分析吉西他滨联合奈达铂化疗治疗鼻咽癌肺转移的临床疗效。方法：90例纳入患者根据其接受的化疗方案分为吉西他滨联合奈达铂化疗组（GN组）、顺铂、5-氟尿嘧啶联合多西他赛化疗组（PTF组）,回顾性分析两组的临床疗效及毒副反应发生情况。结果：GN组治疗有效率为70.0%,较PTF组有明显提高（45.0%）,差异有统计学意义（P〈0.05）;两组疾病控制率分别为94.0%、80.0%,差异无统计学意义（P〉0.05）。GN组白细胞减少、血小板减少Ⅲ~Ⅳ级发生率均较PTF组降低（P〈0.05）。结论：吉西他滨联合奈达铂化疗可进一步提高鼻咽癌肺转移患者预后,化疗相关毒性明显降低,值得临床推广应用。

Objective：To observe and analyze the curative effect of Gemcitabine combined with Nedaplatin chemotherapy on treating 50 cases of lung metastases transform nasopharyngeal carcinoma.Method：90 patients were divided into Gemcitabine combined with Nedaplatin chemotherapy group（GN group） and Cisplatin,5-fluorouracil combined with Docetaxel chemotherapy group（PTF group）,the clinical effect and adverse reactions of two groups were retrospective analyzed.Result：The effective rate of GN group was 70.0%,there was obviously improved compared with the PTF group（45.0%）,the difference was statistically significant（P〈0.05）.The two group’s disease control rates were 94.0% and 80.0%,with no significant difference（P〉0.05）.GN group’s leukopenia and thrombocytopenia grade Ⅲ-Ⅳ incidence rate were lower than than those of PTF group（P〈0.05）.Conclusion：Gemcitabine combined with Nedaplatin chemotherapy can further improve the prognosis of patients with nasopharyngeal carcinoma with lung metastasis,chemotherapy related toxicity was significantly lower,and it is worthy of clinical application.