乌司他丁用于出血性休克危重患者疗效的观察

Curative effect observation of ulinastatin for hemorrhagic shock in critically ill patients

目的：研究探讨乌司他丁同于出血性休克危重患者的临床效果。方法：随机抽取出血性休克危重患者60例为研究对象,并将其随机分成对照组和观察组,每组30例。对照组患者采用常规多巴胺、阿托品药物治疗,观察组患者在常规治疗的基础上同时加用乌司他丁1~2 u/kg治疗。比较两组患者治疗效果。结果：治疗结果显示,观察组患者治疗效果显著优于对照组患者。治疗后两组患者心率、舒张压、收缩压以及平均动脉压均获得改善。观察组患者肝功能各项指标即AST、LDH、ALT显著低于对照组患者,差异有统计学意义（P〈0.05）;同时,同时,观察组患者在手术后肾功能各项指标,即BUN、SCr均低于对照组患者,差异有统计学意义（P〈0.05）。结论：乌司他丁用于出血性休克危重患者显著改善患者的血流动力学,对患者的多个器官起到保护作用,有效辅助治疗出血性休克。

Objective To study on the clinical effect of the ulinastatin he Ding Tong hemorrhagic shock in critically ill patients. Method 60 cases of hemorrhagic shock were randomly selected as the research object. And they were randomly divided into control group and observa- tion group, patients in each group of 30 cases respectively. Control group were treated by routine dopamine, atropine, drug therapy, observation group of patients on the basis of conventional treatment at the same time combined with ulinastatin 1 - 2 u/kg. Compare two groups of patients with therapeutic effect. Results According to the results, of observation group treatment effect of patients was significantly better than the con- trol group patients. In the two groups after treatment in patients with heart rate ,diastolic and systolic blood pressure and mean arterial pressure also got improved. Observation group of patients with liver function indicators that AST, ALT, LDH was significantly lower than the control group patients,data accord with statistical difference （P 〈 0. 05） ;At the same time,the observation group after surgery in patients with renal function indicators, namely, BUN, SCr, were lower than the control group patients data accord with statistical difference （ P 〈 0. 05 ） . Conclusion Ulinastatin for hemorrhagic shock significantly improves hemodynamics in patients with critically ill patients, for patients with multiple organ protection ,effective auxiliary treatment of hemorrhagic shock.