摘要
目的:比较阿立哌唑口腔崩解片和氟哌啶醇治疗抽动障碍的临床疗效和安全性。方法:将符合抽动障碍的61例儿童随机分为两组,分别接受氟哌啶醇和阿立哌唑口腔崩解片治疗,并在治疗2周、4周及8周末分别进行耶鲁综合抽动严重程度量表(Yale Global Tic Severity Scale,YGTSS)、不良反应量表(treatment emergent symptomscale,TESS)评估其疗效和安全性。结果:阿立哌唑口腔崩解片与氟哌啶醇组在治疗的2、4、8周末在YGTSS量表发声抽动、整体损害和YGTSS总分疗效评分上均无明显差异,在2周末运动抽动疗效评分上较氟哌啶醇差;在安全性方面,阿立哌唑口腔崩解片不良反应更小,耐受性更好。结论:阿立哌唑口腔崩解片在治疗抽动障碍上有显著的疗效,和更好地安全性。
Objective To evaluate the efficacy and tolerability of Aripiprazole orally disintegrating tablets and Haloperidol treatment in children with tie disorders. Method 61 Tourette patients were randomly divided into two groups,treatment with Aripiprazole orally disintegra- ting tablets and Haloperidol for 8 weeks. Before treatment and in the second ,fourth and eighth weekend, YGTSSS and TESS were used to eval- uate efficacy and side effects. Results In the 2nd,4th and 8th weekend vocal tic,total damage and total scores of YGTSS both in Aripiprazole group and Haloperidol group significantly decreased. But in the second weekend motor tics score worse than haloperidol. In terms of safety, side effects and tolerance of Aripiprazole orally disintegrating tablets was better. Conclusion Aripiprazole orally disintegrating tabletsis effective for treatment of tic disorder,and high safety.
出处
《吉林医学》
CAS
2015年第14期2995-2997,共3页
Jilin Medical Journal
关键词
抽动障碍
阿立哌唑口腔崩解片
氟哌啶醇
Tic disorders
Aripiprazole orally disintegrating tablets
Haloperidol