喜炎平注射液联合阿奇霉素序贯治疗支原体肺炎患儿疗效观察

Effect of a Sequential Therapy of Xiyanping Injection Combined with Azithromycin on Mycoplasma Pneumonia in the Children

目的:探讨喜炎平注射液联合阿奇霉素序贯治疗支原体肺炎患儿临床疗效观察。方法:将2013年4月至2014年4月109例患儿随机分为对照组(n=53)与观察组(n=56)。对照组仅采用阿奇霉素序贯治疗,观察组在对照组基础上结合喜炎平注射液治疗。对比分析两组治疗后症状消失时间、住院时间、疗效,治疗前后肺功能和血清炎症因子水平变化。结果:观察组治疗后症状消失时间和住院时间均明显低于对照组(P<0.05);观察组总有效率(94.64%)治疗后明显高于对照组(79.25%)(P<0.05);两组FEV1、FVC治疗后较治疗前明显上升(P<0.05),IL-6、TNF-α治疗后较治疗前明显减少;观察组疗后FEV1、FVC明显高于对照组(P<0.05),IL-6、TNF-α明显低于对照组(P<0.05)。结论:喜炎平注射液联合阿奇霉素序贯治疗支原体肺炎患儿临床疗效显著,安全可靠,具有重要临床研究意义。

Objective： To investigate the clinical therapeutic effects of a sequential therapy of Xiyanping injection（ TCM） combined with azithromycin on mycoplasma pneumonia in the children. Method： A total of109 children treated in our hospital between April 2013 and April 2014 were selected and randomly divided into control group（ n = 53） and observation group（ n = 56）. The control group was treated with a sequential therapy of single azithromycin,while the observation group treated with Xiyanping injection additionally.Times to symptom disappearance after the treatment,lengths of stay,therapeutic effects,and changes in lung function and serum inflammatory factor level before and after the treatment of the two groups were contrastively analyzed. Result： The observation group had significantly shorter time to symptom disappearance after the treatment and length of stay than the control group（ P〈0.05）; the total effective rate of the observation group was 94.64%,and was significantly higher than that of the control group（ 79.25%）（ P〈0.05）; both groups had significantly increased in FEV1 and FVC,and less IL-6 and TNF-α after the treatment compared with those before the treatment（ P〈0. 05）; the observation group had significantly higher FEV1 and FVC,and significantly lower IL-6 and TNF-α after the treatment than the control group（ P〈0.05）. Conclusion： The sequential therapy of Xiyanping Injection combined with azithromycin in treatment of mycoplasma pneumonia in the children has significant clinical therapeutic effects,It is safe and reliable,and consequently has important clinical study significances.