肿瘤干细胞标志物CD133在大肠癌组织中的表达及意义

Expression of CD133 in Colonic Cancer and Its Clinical Significance

目的:研究探讨大肠癌组织中肿瘤干细胞表面标记物CD133的表达及临床意义。方法:采用术后大肠癌组织标本60例,应用免疫组织化学法分别检测癌组织和癌旁组织中的CD133的表达情况,分析其与临床病理特征的关系。结果:CD133在大肠癌组织中的表达较癌旁组织增强(P=0.000)。CD133在癌组织中的表达在肿瘤的组织学分化程度、肿瘤浸润深度及是否有淋巴结转移间具有统计学意义(P=0.008,0.014)。结论:CD133在大肠癌组织中过表达,与部分临床病理特征有关,可以作为大肠癌的免疫学诊断候选标记物。

Objective： To investigate the expression of CD133 and its clinical significance in colonic cancer. Method： The expression of CD133 was detected by immunohistochemistry in 60 colonic cancer specimens and the tumor-adjacent tissues. Result： Expressions of CD133 was stronger in tumors than in tumoradjacent tissues（ P = 0.000）. Over-expression of CD133 was correlated with the degree of histological differentiation of tumor,depth of invasion and lymph node metastasis（ P = 0.008,0.014）. Conclusion： CD133 is over-expressed in colonic cancer,and CD133 is related to some clinicopathological characteristics. It is suggested that CD133 can serve as a reliable candidate marker of tumors immunological diagnosis.