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人中性粒细胞载脂蛋白的临床应用进展 被引量：9

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摘要 人中性粒细胞载脂蛋白（human neutrophil lipocalin，HNL）又名人中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinase—associated lipocalin），最初是1994年XU等在中性粒细胞二级颗粒中发现的一种新型分泌型蛋白，与炎症、信号转导、免疫反应及肿瘤的发生发展等过程密切相关。对HNL生物学特征及其与疾病发展机制的研究进一步明确了其在相关疾病诊疗中的价值。
作者 金宇亭 高海翟 张宇 黄晶
机构地区 吉林大学第一医院检验科 长春博德生物技术有限责任公司市场开发与销售部
出处 《广东医学》 CAS 北大核心 2015年第11期1778-1781,共4页 Guangdong Medical Journal
关键词 人中性粒细胞 载脂蛋白 中性粒细胞明胶酶相关脂质运载蛋白 临床应用 lipocalin 生物学特征 信号转导 免疫反应
分类号 R973 [医药卫生—药品]
  • 相关文献

参考文献33

  • 1XU S Y, EARLSON M, ENGSTRM A, et al. Purification and characterization of a human neutrophil lipocalin (HNL) from the secondary granules of human neutrophils[J]. Scand J Clin Lab In- vest, 1994, 54(5) : 365 -376.
  • 2XU S Y, PAUKSEN K, VERGE P, et el. Serum measurements of human neutrophil lipocalin (HNL) discriminate between acute bacterial and viral infections[J]. Scand J Clin Lab Invest, 1995, 55(2) : 125 -131.
  • 3COWLAND J B, SORENSEN O E, SEHESTED M, et al. Neutro- phil gelatinase- associated lipocalin is up -regulated in human epithelial cells by IL- 113, but not by TNF -c~ [ J ]. J Immunol, 2003, 171 (12) : 6630 -6639.
  • 4SCHMIDT OTT K M, MORI K, LI J Y, et al. Dual action of ~ieu- trophil gelatinase - associated lipocalin [J]. J Am Soc Nephrol, 2007, 189(2) : 407 -413.
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二级参考文献15

  • 1Bolignano D,Donato V,Coppolino G,et al.Neutrophil gelatinase -associated lipocalin(NGAL)as a marker of kidney damage.Am J Kidney Dis,2008,52(3):595-605.
  • 2Mori K.Nakao K.Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage.Kidney Int,2007,71(10):967-970.
  • 3Mishra J,Mori K,Ma Q,et al.Amelioration of isehemie acute renal injury by neutrophil gelatinase-associated lipacalin.J Am Soc Nephrol,2004,15(12):3073-3082.
  • 4Mori K,Lee HT,Rapoport D,et al.Endocytie delivery of lipocalin-siderophore-iron cauplex rescues the kidney from ischemia-reperfusion injury.J Clin Invest,2005,115(3):610-621.
  • 5Bolignano D,Coppolino G,Campo S,et al.Urinary neutrophil gelatinase-associated lipocalin(NGAL)is associated with severity of renal disease in proteinuric patients.Nephrol Dial Transplant,2008,23(1):414-416.
  • 6Mishra J,Ma Q,Prada A,et al.Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury.J Am Soc Nephrol,2003,14(10):2534-2543.
  • 7Mishra J,Dent C,Tarabishi R,et al.Neutrophil gelatinase-associated lipocalin(NGAL) as abiomarker for acute renal injury after cardiac surgery.Lancet,2005,365(9466):1231-1238.
  • 8MBj?rkqvist,JK?llman,GFjaertoft,SXu,PVenge,JSchollin.Human neutrophil lipocalin: normal levels and use as a marker for invasive infection in the newborn[J].Acta P?diatrica.2007(4)
  • 9S. Y. Xu,K. Pauksen,P. Venge.Serum measurements of human neutrophil lipocalin (HNL) discriminate between acute bacterial and viral infections[J].Scandinavian Journal of Clinical & Laboratory Investigation.1995(2)
  • 10S. Y. Xu,M. Carlson,A. Engstr?m,R. Garcia,C. G. B. Peterson,P. Venge.Purification and characterization of a human neutrophil lipocalin (HNL) from the secondary granules of human neutrophils[J].Scandinavian Journal of Clinical & Laboratory Investigation.1994(5)

共引文献29

同被引文献46

  • 1Xu SY, Carlson M, Engstrm A, et al. Purification and character- ization of a human neatrophil lipocalin (HNL) from the secondary granules of human neutrophils [ J ]. Scand J Clin Lab Invest, 1994,54(5 ) :365-376.
  • 2Venge P, Douhan-Htikansson L, Garwicz D, et al. Human neutro- phil lipocalin as a superior diagnostic means to distinguish between acute bacterial and viral infections[ J]. Clin Vaccine Immunol, 2015,9(22) :1025-1032.
  • 3Bone RC, Balk RA, Cerra FB,et al. Definitions for sepsis and or- gan failure and guidelines for the use of innovative therapies in sep- sis. The ACCP/SCCM Consensus Conference Committee. Ameri- can College of Chest Physicians/Society of Critical Care Medicine [ J], Chest, 1992,101 (6) :1644-1655.
  • 4Cowland JB, Scrensen OE, Sehested M, et al. Neutrophil gelati- nase-associated lipocalin is up-regulated in human epithelial cells by IL-113, but notby TNF-a[ J]. J Immunol, 2003,171 (12) : 6630-6639.
  • 5Schmidt-Ott KM, Mori K, Li JY, gelatinase-associated lipocalin [ J ] (2) :407-413. et al. Dual action of nelatrophil J Am Soc Nephrol, 20i)7,189.
  • 6Fjaertoft G, Xu S, Venge P, et al. Human neutrophil lipocalin: normal levels and use as a marker for invasive infection in the new- bom[ J]. Acta Paediatr, 2004,3 (4) :534-539.
  • 7Fjaertoft G, Foucard, XU S, et al. Human neutrophil lipocalin (HNL) as a diagnostic tool in children with acute infections: A study of the kinetics [ J ]. Acta Paediatrica, 2005,94 ( 6 ) 661- 666.
  • 8杨泽平,聂国明,邹敏书.中性粒细胞脂钙素在儿童急性细菌感染中的临床意义[J].临床荟萃,2008,23(20):1491-1493. 被引量：4
  • 9蒋奶贵,许丽艳,郭明洲,李恩民.肿瘤相关蛋白NGAL的生物学特征[J].胃肠病学和肝病学杂志,2010,19(4):297-301. 被引量：14
  • 10薛志强,童俊容.慢性肾脏疾病血清和尿液NGAL的改变及其临床意义[J].中国中西医结合肾病杂志,2010,11(5):440-441. 被引量：22

引证文献9

二级引证文献83

广东医学
2015年 第11期

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