胃癌患者癌旁黏膜炎症与幽门螺杆菌感染的关系

Relationship of Helicobacter pylori infections with mucosal inflammation in different types of gastric cancer

目的研究不同类型胃癌患者癌旁黏膜炎症与幽门螺杆菌(Hp)感染的关系,为临床治疗提供依据。方法选取2013年1-12月胃癌患者182例,分析比较患者Hp感染、类型、组织学类型、肿瘤生长部位、癌旁黏膜炎症等,所有数据采用SPSS 20.0进行统计分析。结果肠型胃癌患者与弥漫型胃癌患者性别、生长部位及Hp感染差异无统计学意义,但年龄差异有统计学意义(P<0.05);不同分型、组织病理分型胃癌患者间Hp感染率差异无统计学意义;Hp感染率贲门癌为42.59%、胃窦及胃体癌为66.41%,差异有统计学意义(P<0.05);肠型与弥漫型胃癌患者间Hp感染率在慢性活动性胃炎、慢性非活动性胃炎中差异无统计学意义,但在萎缩型胃炎、肠上皮化生中差异有统计学意义(P<0.05)。结论 Hp感染常发生于非贲门癌患者,Hp感染阳性慢性胃炎是发生肠型和弥漫型胃癌的基础病变。

OBJECTIVE To study the relationship of Helicobacter pylori（hp）infections with mucosal inflammation in different types of gastric cancer,so as to provide basis for clinical treatment.METHODS Totally 182 cases of patients with gastric cancer from Jan.to Dec.2013 were selected,and analyzed and compared for Hp infections,types,histological types,tumor locations,and adjacent mucosal inflammation.The software SPSS 20.0was used for statistical analysis for all data.RESULTS Differences in genders,growth sites and Hp infections between gastric cancer patients of intestinal types and those of diffuse types were not significant,however,the difference in age was significant（P〈0.05）.The Hp infection rate for cardiac cancer,gastric antrum and corpus cancer was 42.59% and 66.41%,with significance（P〈0.05）.Differences in Hp infection rate in chronic active gastritis and chronic inactive gastritis between patients with intestinal and diffuse gastric cancer were not significant,however,differences in atrophic gastritis and intestinal metaplasia were significant（P〈0.05）.CONCLUSION Hp infections often occur in non-cardiac cancer patients,Hp-positive infections in chronic gastritis are fundamental lesions of intestinal and diffuse gastric cancer.