口服胰岛素纳米粒的吸收机制

Absorptive mechanisms of oral insulin nanoparticles

胰岛素口服给药可以显著改善糖尿病患者的生活质量，然而，胃肠道中各种生理障碍限制了胰岛素的口服吸收。将胰岛素用特定的聚合纳米材料封装可增加口服胰岛素的生物利用度。载胰岛素纳米粒可通过细胞旁路和跨细胞途径穿过肠上皮细胞层，其吸收机制可能是通过增加与黏膜相互作用或可逆性打开相邻细胞紧密连接。

Oral delivery of therapeutic insulin can significantly improve the quality of life of diabetic patients. However,oral absorption of insulin is limited by various physiological barriers in the gastrointestinal tract. The encapsulation of insulin into specific polymer-based nanoparticles can increase the oral bioavailability of insulin. Nanoparticles can transport across the intestinal epithelium via the paracellular route or transcellular route. The absorptive mechanisms of insulin delivered by nanoparticles may increase the interactions with the intestinal mucosa or open tight Junctions between contiL, uous enithelial cell~ r^versiblv.