围生期孕产妇应用亚胺培南/西司他丁钠的治疗药物监测

Therapeutic drug monitoring for peripartum use of imipenem/cilastatin

目的探讨治疗药物监测手段支持围生期孕妇应用亚胺培南/西司他丁钠治疗的作用。方法 1名孕29周患者因宫内感染使用亚胺培南/西司他丁钠进行抗感染治疗,为明确药物使用的安全性,临床药师通过治疗药物监测手段,协助临床科室进行围生期抗感染治疗。结果与结论对母体静脉血及胎儿脐带血进行血药浓度监测发现,母体及胎儿的血药浓度均在安全范围,通过随访,母婴均恢复良好出院。临床药师为临床特殊患者进行治疗药物监测,为围生期使用美国食品药品监管理局妊娠分级C级的抗菌药物积累了应用经验和药学监护方法。

Objective To report a case of peripartum use of imipenem /cilastatin supported by therapeutic drug monitoring（TDM） technique.Methods A 29-week pregnant woman was prescribed imipenem / cilastatin because of intrauterine infection,to ensure the safety of this Food and Drug Administration（FDA） Class C drug,pharmacists carried out TDM for this patient.Results and Conclusion By establishing a rapid analyzing method,the parent venous blood and fetus umbilical cord blood was measured.The concentration of imipenem / cilastatin were within normal range in both the mother and the baby.Through follow-up,no adverse event were developed and both were discharged later.By providing TDM and pharmaceutical care,the pharmacists supported the clinical usage of peripartum anti-infectious therapy,and more experience and confidence would be gained and shared.