血尿酸与中青年急性脑梗死的相关性分析

Correlation between the level of serum uric acid and acute cerebral infarction in young and middle-aged patients

目的：探讨血尿酸（ UA）水平与中青年急性脑梗死（ ACI）的关系。方法：选择96例中青年ACI患者为脑梗死组,以同期健康体检者100名为对照组,比较2组空腹血糖、血UA、三酰甘油、总胆固醇、低密度脂蛋白及高密度脂蛋白水平。结果：脑梗死组UA水平（382±110）μmol/L,明显高于对照组的（266±101）μmol/L（P〈0.01）；脑梗死组UA异常率为32.99%,明显高于对照组的12.00%（P〈0.01）；logistic 回归分析显示,在校正了总胆固醇、三酰甘油、空腹血糖及低密度脂蛋白后,UA水平仍与中青年ACI呈正相关关系（OR=1.006,95%CI：1.003~1.011,P〈0.05）。结论：UA水平是中青年ACI的危险因素之一。

Objective：To explore the relationship between the level of serum uric acid（UA） and acute cerebral infarction（ACI） in young and middle-aged patients. Methods：Ninty-six young and middle-aged patients with ACI and 100 healthy people were divided into the ACI group and control group,respectively. The fasting serum glucose,UA,triglyceride,total cholesterol,high density lipoprotein and low density lipoprotein in two groups were compared. Results：The level of serum UA in ACI group （ 382 ± 110 ）μmol/L was significantly higher than that in control group（266 ±101）μmol/L（P〈0. 01）. The abnormal rate of UA in ACI group（32. 99%） was significantly higher than that in control group（12. 00%）（P〈0. 01）. After triglyceride,total cholesterol,high density lipoprotein and low density lipoprotein were adjusted,logistic regression analysis demonstrated that the level of serum UA was positive correlation with the ACI（OR=1. 006,95%CI：1. 003 to 1. 011,P〈0. 05）. Conclusions：The level of serum UA is one of risk factors of ACI in young and middle-aged patients.