新生儿高胆红素血症换血治疗的血液指标分析

Analysis on the blood indexes of exchange transfusion in neonates with hyperbilirubinemia

目的:探讨换血治疗对于新生儿高胆红素血症患儿血液指标的影响。方法:对32例高胆红素血症患儿采用外周动静脉同步换血治疗,并检测换血前后患儿血清中的生化、血常规以及动脉血气指标。结果:换血治疗后总胆红素和间接胆红素均显著降低(P<0.01);白细胞和血小板亦均明显降低(P<0.01);红细胞和血红蛋白变化差异均无统计学意义(P>0.05);血糖显著升高(P<0.01);血钾、血钠、血氯、血钙、p H和碱剩余变化差异均无统计学意义(P>0.05)。结论:新生儿高胆红素血症换血治疗后胆红素显著性降低,但同时对白细胞、血小板、血糖等血液指标有较大的影响,故术中、术后应及时检测生化和血常规,以防电解质紊乱和出血、感染的发生。

Objective： To explore the influence of blood exchange transfusion on blood parameters in neonates with hyperbilirubinemia. Methods：Thirty-two hyperbilirubinemia neonates were accepted to do exchange transfusion by peripheral artery and vein synchronously,the serum biochemical parameters,blood routine indexes,and arterial blood gas analysis were detected before and after exchange transfusion. Results：After exchange transfusion,the serum total bilirubin and indirect bilirubin levels were significantly lower than before（P〈0. 01）;white blood cells and platelets levels were decreased（P〈0. 01）;red blood cells and hemoglobin levels had no statistically significant differences（P〉0. 05）;blood sugar level was elevated significantly（P〈0. 01）;blood potassium,sodium, chloride,calcium concentrations,pH and base excess change had no statistical differences（P〉0. 05）. Conclusions：Serum bilirubin level was decreased significantly after exchange transfusion in hyperbilirubinemia neonates,but blood indexes such as white blood cells, platelets,blood sugar also had changed,so it is need to detect biochemical parameters and blood routine indexes in order to prevent the happening of electrolyte disorder and hemorrhage,infection.