医用316L不锈钢表面多巴胺/BSA复合膜缓蚀性能研究

Corrosion Inhibition Performance of Composite Dopamine/BSA Film on Medical 316L Stainless Steel Surface

目的研究医用316L不锈钢表面组装多巴胺/牛血清白蛋白分子(BSA)复合膜的缓蚀性能。方法采用浸泡法在医用316L不锈钢表面制备以多巴胺自组装膜为桥接层的多巴胺/BSA复合双层自组装膜,通过动电位扫描、交流阻抗测试,SEM,EDX等手段分析BSA组装液质量浓度对复合双层自组装膜吸附行为及耐蚀性能的影响。结果在合适的自组装条件下可获得具有缓蚀效果的复合双层膜。BSA质量浓度过高和过低均对缓蚀性能有不利影响,当BSA质量浓度为40 g/L时,复合双层膜对生理盐水环境中316L不锈钢取得最佳缓蚀效率,缓蚀效率由单层多巴胺的62.4%增加至83.9%。结论多巴胺成功嫁接BSA分子,使其吸附在不锈钢表面,和单层BSA吸附相比,其吸附量大大提高,表明对于316L不锈钢人体植入材料,可以利用多巴胺桥接BSA获得兼具生物活性和耐腐蚀性的改性表面。

Objective To study the corrosion inhibition performance of composite dopamine （DP）/bovine serum albumin （BSA） film on the medical 316L stainless steel surface. Methods The dopamine/BSA composite self-assembled bilayer film was prepared by soaking method on the surface of 316L stainless steel （316L SS） by using DP as the bridge layer. The effect of BSA mass concentration on the adsorption behavior and the corrosion inhibition performance of the bilayer film was studied by potentiodynamic scanning, electrochemical impedance spectroscopy （EIS）, scanning electron microscopy （SEM） and energy dispersive Xray detection （EDX）. Results The composite self-assembled hilayer film showed corrosion inhibition effect in the appropriate condition. Too high and too low BSA mass concentrations were both unfavorable for the corrosion inhibition performance of the film.The optimum corrosion inhibition efficiency for 316L SS in physiological saline environment was obtained at the BSA mass concentration of 40 g/L, and the corrosion inhibition efficiency increased form 62.4% of the single DP film to 83.9% of the DP/BSA bilayer film. Conclusion The results show that DP molecules successfully graft BSA onto the surface of 316L stainless steel and the adsorption capacity is great improved compared with the single BSA film. It shows that the modified 316L SS surface with good corrosion resistance and biocompatibilitv can be obtained by using dopamine as the adhesive layer to graft BSA onto the substrate.