丝素蛋白微针溶胀给药系统的研究

Study on Silk Fibroin Microneedle Swelling Drug Delivery System

研究了一种微针溶胀给药系统,采用生物相容性良好的丝素蛋白为微针基材,将丝素溶液浇注于聚二甲基硅氧烷模具中,经过抽真空、恒温恒湿干燥成型,获得丝素干凝胶微针。为了获得溶胀型微针,加入乙二醇甲醚、尿素等小分子溶胀剂与丝素蛋白共混,研究了微针溶失、溶胀、压缩强度、药物释放等性能。采用X射线衍射测试了丝素蛋白微针干、湿态下的结晶结构。结果表明:加入的乙二醇甲醚与丝素质量比为1︰10时,丝素蛋白微针溶失性小,溶胀性能、强度、透皮释药速率及释药率较好。

In this paper, new microneedle swelling drug delivery system was studied. Silk fibroin with good biocompatibility was used as basic material of microneedle. Fibroin solution was poured in polydimethylsiloxane mould. Fibroin xerogel microneedle was gained through vacuumizing and drying with constant temperature and humidity. To obtain swelling microneedle, ethylene glycol monomethyl ether, urea and other micromolecule swellers were mixed with silk fibroin to study dissolution loss, swelling, compression strength and drug release properties of microneedle. X-ray diffraction was adopted to test crystalline structure of silk fibroin microneedle under dry and wet state. The results show that when the mass ratio of ethylene glycol monomethyl ether and fibroin is 1 ： 10, dissolution loss of silk fibroin microneedle is small; swelling property, strength, transdermal drug release rate and drug release efficiency are good.