三酰甘油及高密度脂蛋白胆固醇与脑出血的关系研究

Correlation between TG,HDL-C and Cerebral Hemorrhage

目的探讨三酰甘油(TG)和高密度脂蛋白胆固醇(HDL-C)与脑出血的关系。方法选取2011年2月—2012年3月汕头市潮阳区大峰医院收治的脑疾病患者168例,其中脑出血患者112例(研究组),非脑出血患者56例(对照组),再将脑出血组患者按不同出血部位分为4个亚组,即基底核出血组54例、脑叶出血组27例、幕下出血组21例、脑室出血组10例。回顾性分析患者的一般资料(性别、年龄、心率、高血压史、吸烟史、酗酒史)、血脂指标〔总胆固醇(TC)、TG、低密度脂蛋白胆固醇(LDL-C)、HDL-C、载脂蛋白A1(Apo A1)、载脂蛋白B(Apo B)〕,并分析其与脑出血的关系。结果两组患者性别、年龄、心率、TC、LDL-C、Apo A1水平比较,差异无统计学意义(P>0.05);研究组患者高血压发生率、吸烟率、酗酒率、TG、Apo B水平高于对照组,HDL-C水平低于对照组(P<0.05)。多因素Logistic回归分析结果显示,男性、年龄>60岁、吸烟、酗酒、高血压、TG≥1.70 mmol/L、HDL-C<3.12 mmol/L是脑出血的危险因素(P<0.05)。4亚组患者HDL-C水平比较,差异无统计学意义(P>0.05);脑叶出血组患者TG、TC及LDL-C水平均低于基底核出血组、幕下出血组及脑室出血组(P<0.05)。结论TG≥1.70 mmol/L、HDL-C<3.12 mmol/L是脑出血的危险因素,可作为临床筛查及诊断脑出血的参考指标。

Objective To investigate the correlation between TG,HDL-C and cerebral hemorrhage.Methods From February 2011 to March 2012 in Dafeng Hospital of Chaoyang District,Shantou,a total of 168 patients with encephalopathy were selected,and they were divided into case group（with cerebral hemorrhage,n = 112） and control group（without cerebral hemorrhage,n = 56） according to the incidence of cerebral hemorrhage.According to hemorrhage positions,patients of case group were divided into four subgroups：A group with basal ganglia hemorrhage（n = 54）,B group with cerebral lobe hemorrhage（n = 27）,C group with lower tentorium hemorrhage（n = 21）,D group with cerebral ventricle hemorrhage（n =10）.General information including gender,age,heart rate,hypertension history,smoking history,drinking history,blood lipids index including TC,TG,LDL-C,HDL-C,Apo A1,Apo B were retrospectively analyzed,and their correlations with cerebral hemorrhage were analyzed.Results No statistically significant differences of gender,age,heart rate,TC,LDL-C or Apo A1 was found between case group and control group（P〉0.05）;while incidence of hypertension,smoking rate,drinking rate,TG and Apo B of case group were statistically significantly higher than those of control group,HDL-C of case group was statistically significantly lower than that of control group（P〈0.05）.Multivariate Logistic regression analysis showed that,male,age〉 60 years old,smoking,drinking,hypertension,TG ≥1.70 mmol / L,HDL-C 〈3.12 mmol / L were risk factors of cerebral hemorrhage（P〈0.05）.No statistically significant differences of HDL-C was found among the four subgroups（P〉0.05）,while TG,TC and LDL-C of B group was statistically significantly lower than that of groups A,C,D,respectively（P〈0.05）.Conclusion TG≥1.70 mmol / L,HDL-C 〈3.12 mmol / L are risk factors of cerebral hemorrhage,and can be used as screening or diagnostic index for cerebral hemorrhage.