针刺联合脐环穴隔姜灸治疗脾肾阳虚型溃疡性结肠炎临床疗效及对相关炎性因子的影响

Therapeutic Effect of Acupuncture Combined with Umbilical Ring Point Ginger-partition Moxibustion for Ulcerative Colitis of Spleen-kidney Yang Deficiency Type and Its Influence on Related Inflammatory Factors

【目的】研究针刺联合脐环穴隔姜灸治疗脾肾阳虚型溃疡性结肠炎临床疗效及对相关炎性因子的影响。【方法】将符合纳入标准的60例患者随机分为治疗组和对照组各30例。对照组给予口服双歧三联活菌胶囊治疗,治疗组在与对照组相同的口服药物治疗基础上,给予普通针刺及脐环穴隔姜灸治疗。观察2组治疗1个疗程(4周)后的临床疗效及治疗前后相关炎性因子血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)含量变化情况,并评价其治疗的安全性。【结果】(1)在临床疗效方面,治疗组的总有效率为86.67%,对照组为66.67%,治疗组的疗效显著优于对照组(P<0.05);(2)在相关炎性因子方面,治疗后2组血清TNF-α、IL-8含量均较治疗前显著下降(P<0.05或P<0.01),且治疗组的降低作用均优于对照组(P<0.05)。(3)在安全性方面,治疗过程中,所有患者均未出现明显不良反应。【结论】针刺联合脐环穴隔姜灸治疗脾肾阳虚型溃疡性结肠炎有较好的临床疗效和较高的安全性。

Objective To investigate the therapeutic effect of acupuncture combined with umbilical ring point ginger-partition moxibustion for ulcerative colitis of spleen-kidney yang deficiency type, and to observe its influence on the related inflammatory factors. Methods Sixty qualified cases were randomly divided into treatment group and control group, 30 in each group. Both groups were given oral use of live combined bifidobacterium, lactobacillus and enterococcus capsules, and the treatment group received acupuncture and umbilical ring point ginger-partition moxibustion together. After one treatment course（four weeks）, the therapeutic effect was evaluated, and the changes of serum levels of related inflammatory factors of tumor necrosis alpha（TNF-α） and interleukin 8（IL-8） were observed. Moreover, the safety was monitored. Results（1） The total effective rate was 86.67% in the treatment group and 66.67% in the control group, the difference being significant between the two groups（P〈0.05）.（2） The serum TNF-α and IL-8 levels were decreased in both groups after treatment（P〈0.05 or P〈0.01）, and the decrease in the treatment group was superior to that in the control group（P〈0.05）.（3） No obvious reverse action was found in the two groups. Conclusion Acupuncture combined with umbilical ring point ginger-partition moxibustion is effective and safe for the treatment of ulcerative colitis of spleen-kidney yang deficiency type.