不同频率机采血小板对献血者血小板生成素的影响

The influence on the TPO from platelets collected from donors at different frquency

目的了解不同频率机采血小板对献血者血小板生成素的影响。方法随机分别选取连续多次半个月、1个月和3个月捐献1次机采血小板的献血者,对其机采前的血小板生成素(TPO)、血小板(PLT)、平均血小板体积(MPV)进行统计分析。结果连续多次半个月机采1次血小板献血者的PLT升高、MPV和TPO下降,第2、3、4、5次采集与第1次相比差异有统计学意义(P<0.01);连续1个月机采1次血小板献血者的TPO下降,第2次采集与第1次相比差异有统计学意义(P<0.05),从第3次机采开始TPO下降(P<0.01),而PLT和MPV无明显变化(P>0.05);连续3个月机采1次血小板献血者的PLT、MPV和TPO与第1次相比皆无明显变化(P>0.05)。结论不同频率机采血小板对献血者的PLT、MPV和TPO的影响不同;1个月和3个月机采1次血小板是相对安全的,能缓解目前血小板短缺的状况。

Objective To Investigate the influence on TPO of platelets collected at different frequency of blood donation.Methods the TPO, Plt and MPV of donors before platelet donating are determined and analyzed in randomly selecting donors who donate platelet consecutively 15, 30, 90 day once. Result Compared with the first time, the second, third, fourth time＇s Plt was elevated and MPV, TPO are declined from consecutive 15 day in platelet donors（P〈0.01）. In the consecutive 30 day once platelet donors, the TPO was declined（the second time compared with the first time P〈0.05 and beginning from the third time P〈0.01）, but there is no difference between Plt and MPV（P〉0.05）.There is no difference between Plt, MPV and TPO from consecutive 90 day once platelet donors（P〉0.05）. Conclusion The influence is different for Plt, MPV and TPO between different frequency of platelet donation. It is relatively safe from consecutive 30, 90 day once for donating platelets, Plt deficit could be hence avoided.