完全控制的支气管哮喘患者186例临床分析

Clinical analysis of 186 patients with totally controlled asthma

目的探讨获得完全控制的支气管哮喘患者临床特征。方法收集2012年1月至2014年6月深圳市龙岗区人民医院呼吸内科经过规范治疗获得完全控制的支气管哮喘患者186例临床资料与健康对照组进行统计分析。结果完全控制的支气管哮喘患者肺功能指标FEV1%、FEV1/FVC%低于正常对照组,有统计学意义(P<0.01),血清总Ig E及外周血EOS显著高于正常对照组(P<0.01),获得完全控制的支气管哮喘患者不同剂量药物组之间肺功能检查指标FEV1%、FEV1/FVC%无统计学差别(P>0.05)。结论完全控制的支气管哮喘患者肺功能并未恢复正常,仍然存在气道炎症,需要继续抗炎治疗。

Objective To explore the clinical characteristics of patients with totally controlled asthma. Methods 186 patients with totally controlled asthma from January, 2012 to June, 2014 were enrolled in the study and 28 healthy subjects were selected as the control group. Results The forced expiratory volume in one second （FEV1% ） and the forced vital capacity rate of one second （FEV1 / FVC% ） was significant lower in the study group than in the control group （P 〈 0. 01）. The serum levels of immunoglobulin E and eosinophil were significant higher in the study group than in the control group （P 〈 0. 01）. There was no significant difference in FEV1% and FEV1 /FVC% in patients with controlled asthma treated with different dose drugs （P 〉 0. 05）. Conclusion The lung func-tion of patients with totally controlled asthma don′t return to normal, and they still have airway inflammation and need to be given anti-inflammatory treatment.