血清血管紧张素转换酶的水平在阻塞性睡眠呼吸暂停低通气综合征患者中的变化研究

Change of serum angiotensin-converting enzyme level in patients with obstructive sleep apnea-hypopnea syndrome

目的检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者中血清血管紧张素转换酶(ACE)水平的变化及其临床意义。方法设置OSAHS组(n=40)和健康对照组(n=40),测定并比较患者的血压、血脂和血清ACE水平在两组间的差异;分析ACE水平与患者病情变化、血压、血脂的相关性。结果 OSAHS患者在体重、BMI指数、颈围、腰围、AHI、收缩压、舒张压、TC、LDL-C和血清ACE方面高于健康人(P体重=0.002,P颈围=0.024,P腰围=0.038,PBMI=0.019,PAHI=<0.001,P收缩压=<0.001,P舒张压=<0.001,PTC=0.017,PLDL-C=0.010,PACE=0.039),在LSa O2上低于健康人(PLSa O2=<0.001)。OSAHS患者的收缩压、TC、ACE在轻中度和中重度之间均存在统计学差异(P收缩压=0.018、0.043,PTC=0.045、0.034,PACE=0.030、0.001),相关性分析显示,OSAHS患者中血清ACE与收缩压和TC均呈正相关(r=0.35,P=0.017;r=0.28,P=0.044)。结论 OSAHS患者血清ACE能反映患者病情的变化,并与血压和血脂具有一定相关性。

Objective To detect the change of serum angiotensin-converting enzyme （ACE） level in pa-tients with obstructive sleep apnea-hypopnea syndrome （OSAHS）. Methods The study selected 40 OSAHS patients as the study group and 40 healthy people as the control group. The relationship of ACE to blood pressure, disease se-verity and lipid was analyzed. Results The value of weight, BMI, neck and waist circumference, AHI, blood pres-sure, TC, LDL-C and serum ACE was higher in the study group than in the control group （P 〈 0. 05）, and the value of LSaO2 was lower in the study group than in the control group （P 〈 0. 01）. There were significant differences in systolic pressure, TC and ACE between the mild and moderate, moderate and severe OSAHS groups （P 〈 0. 05）. ACE was positively correlated with systolic pressure and TC in OSAHS patients （r = 0. 35, P = 0. 017; r = 0. 28, P =0. 044）. Conclusion The serum ACE level reflects the change of OSAHS, and it is positively correlated with systol-ic pressure and TC.