高频振荡通气联合蛇毒血凝酶治疗新生儿肺出血的疗效

Effect of high frequency oscillatory ventilation combined with hemocoagulase in the treatment of neonatal pulmonary hemorrhage

目的 观察高频振荡通气联合蛇毒血凝酶治疗新生儿肺出血的疗效。方法 选取我院自2011年12月-2013年12月收治入院的新生儿肺出血患儿67例,随机分为观察组34例及对照组33例,对照组给予常规治疗及高频振荡通气,观察组在对照组的基础上给予蛇毒血凝酶治疗,观察两组患儿的出血停止时间、临床疗效及不良反应。结果 观察组与对照组在肺出血停止时间、机械通气时间、住院时间上比较差异具有统计学意义。观察组与对照组在总有效率比较上差异具有统计学意义。结论 采用高频振荡通气联合蛇毒血凝酶治疗新生儿肺出血疗效显著,可明显缩短肺出血停止时间、机械通气时间、住院时间,且无明显不良反应。

Objective To observe the effect of high frequency oscillation ventilation combined with hemo-coagulase in the treatment of neonatal pulmonary hemorrhage. Methods 67 neonatal pulmonary hemorrhage patients in our hospital from December 2011 to December 2013 were randomly divided into the observation group and the con-trol group. The control group was given conventional treatment and high-frequency oscillatory ventilation, and the ob-servation group received the treatment of blood coagulation enzyme from snake venom. The bleeding time, clinical effect and adverse reactions were observed in the two groups. Results There were significant differences in pulmona-ry hemorrhage stopping time, mechanical ventilation time and duration of hospital stay between the two groups. The total effective rate was better in the observation group than in the control group. Conclusion High-frequency oscilla-tory ventilation combined with hemocoagulase can shorten bleeding time, mechanical ventilation time, duration of hos-pital stay in the treatment of neonatal pulmonary hemorrhage, without obvious adverse reaction.