摘要
目的研究白花败酱草乙醇提取物对小鼠抗氧化作用的影响。方法取昆明种小鼠32只,随机分为生理盐水组,5.0、10.0、20.0 mg/kg白花败酱草乙醇提取物组。连续给药10 d,次日小鼠拉颈椎脱臼处死,取心、脑、肝等组织,检测心、脑、肝等组织中的超氧化物歧化酶(SOD)的活性、丙二醛(MDA)的含量。结果 10.0、20.0 mg/kg白花败酱草乙醇提取物能显著升高小鼠心、脑、肝等组织中SOD活性(P<0.05或P<0.01),显著降低心、脑、肝等组织中MDA含量(P<0.05或P<0.01)。结论白花败酱草乙醇提取物可清除体内脂质过氧化物,减轻机体的过氧化损伤,具有明显的抗氧化作用。
Objective To study the antioxidant effect of ethanol extract of Patrinia villosa Juss. in mice model. Methods Thirty-two Kunming mice were randomly divided into 4 groups,intragastric administrated for 10 consecutive days,with normal saline and different doses of ethanol extract of Patrinia villosa Juss.（5.0,10.0,20.0 mg/kg）,respectively.The mice were sacrificed by cervical dislocation,the activity of superoxide dismutase（SOD） and the content of malondialdehyde（MDA）in mice hearts,brains and livers were determined by kits respectively. Results Ethanol extract of Patrinia villosa Juss. at10.0 mg/kg and 20.0 mg/kg dose could significantly increase the SOD activity（P〈0.05 or P〈0.01）,and decrease the MDA content in mice hearts,brains and livers（P〈0.05 or P〈0.01）. Conclusion Ethanol extract of Patrinia villosa Juss. can eliminate the lipid peroxides and release the peroxidation injury,it shows significant antioxidation effect in mice model.
出处
《中国当代医药》
2015年第18期4-5,10,共3页
China Modern Medicine
