奥曲肽和生长抑素治疗肝硬化上消化道出血的效果观察

Effects of octreotide and somatostatin in treatment of liver cirrhosis and upper digestive tract hemorrhage

目的 探讨奥曲肽和生长抑素治疗肝硬化上消化道出血的优劣性。方法 选择本院2012年3月-2014年5月收治的肝硬化上消化道出血患者114例,将其随机分为实验组57例和对照组57例,实验组患者给予生长抑素进行治疗,对照组患者给予奥曲肽进行治疗,观察记录两组患者的治疗效果、止血时间及不良反应的发生情况。结果 实验组患者与对照组患者的治疗总有效率比较,差异无统计学意义（P〉0.05）;实验组患者的止血时间显著短于对照组,实验组不良反应发生率显著低于对照组,差异有统计学意义（P〈0.05）。结论 两种药物治疗肝硬化上消化道出血均有较理想的效果,但生长抑素止血更迅速,且不良反应更少,值得临床推广。

Objective To investigate the pros and cons of octreotide and somatostatin in treatment of liver cirrhosis and upper digestive tract hemorrhage. Methods 114 cases of cirrhosis with upper gastrointestinal hemorrhage patients in our hospital from March 2012 to May 2014 were selected,and were divided into experimental group 57 cases and control group 57 cases in random.The patients in experimental group were treated with somatostatin,the patients in control group were treated with octreotide.The treatment effect,hemostasis time,and the occurrence of adverse reactions of patients between two groups was recorded respectively. Results The hemostasis time of experimental group was significantly lower than that in control group,and the incidence of adverse reactions in experimental group patients was significantly lower than that in control group,with statistical difference（P〈0.05）. Conclusion Two kinds of drugs in the treatment of liver cirrhosis with upper digestive tract hemorrhage have an ideal effect,but compared with octreotide,somatostatin for hemostasis more quickly and with less adverse reactions,it is worthy of clinical promotion.