头孢他美酯的合成实验研究

Experimental Study on the Synthesis of Cefetamet Pivoxil

目的探讨头孢他美酯的合成实验方法。方法本次实验当中所使用的合成原料为3-去乙酰氧基-7氨基头孢烷酸,首先利用AE-活性酯对其进行缩合处理,生成头孢他美,然后再利用特戊酰碘甲酯对其进行酯化反应,进而生成头孢他美酯。结果由于β-内酰胺环对于酸碱性溶液均表现为极不稳定的性质,因此在合成过程中,在加入碱性溶液时应该降低温度,并且选择特戊酸碘甲酯能够有效提高催化效率,使得产率达到90%以上,产物浓度达到99%以上,提高合成效率。结论利用本次研究所使用的方法能够有效提升合成效率和产物产出率,并且操作简便,能够被用于批量生产当中。

Objective To investigate the synthetic method of Cefetamet Pivoxil.Methods The use of synthetic materials,including 3-to acetoxy-7 amino cephalosporanic acid,firstly by using AE active ester of the condensation process,generation of cefetamet,and then the pivaloyl iodine methyl esterification of the and generation cephalosporin cefetamet Pivoxil.Results Due to the beta lactam ring for the pH value of the solution are highly unstable nature of,so in the synthetic process,in alkaline solution by adding should reduce the temperature,and select iodomethyl pivalate can effectively improve the catalytic efficiency,the yield reached more than 90%,the product concentration reached more than 99%,and increase the efficiency of the synthesis.Conclusion The use of this research method can effectively improve the synthesis efficiency and the product output rate,and is simple,can be used in mass production.