平行四面体纳米孔道中DNA超结构的组装和离子输运特性

Ion Transport in DNA Superstructure Modified Diamond-shaped Nanopores

受生物膜离子通道结构和功能的启发,人工制备固体纳米孔道门控开关器件一直备受关注.基于仿生纳米孔道的非对称离子传输性质制备的离子二极管和场效应管装置对于构建离子电路和能量转换的纳米器件至关重要.然而,仿生制备的固体纳米孔道在离子传输过程中有漏电流的存在,严重影响了固体纳米孔道应用的灵敏度和信噪比.针对这一问题,研究者利用DNA分子的特殊识别和自组装的功能特性,相继构筑了基于DNA和纳米孔道的智能响应体系.

Inspired by the biological ion channels, DNA supersandwich structures were self-assembled in diamond-shaped mica nanopores, forming highly efficient gate-like nanofluidic switch. Through asymmetric DNA modification in the mica nanopores, rectified ion transport property was observed. The results revealed that DNA, the flexible biological molecules, can also be used to build nanofluidic devices for gating and rectification function in solid-state nanopores with parallel tetrahedron structures.