PR、ER、NCOR及SRC-1在高强度聚焦超声治疗外阴营养不良中的表达

Expressions of progesterone receptor,estrogen receptor,nuclear receptor corepressor,and steroid receptor coactivator-1 in vulval dystrophy treated by high-intensity focused ultrasound

目的探讨妇女外阴营养不良(增生型)在高强度聚焦超声(HIFU)治疗后上皮组织中孕激素受体(PR)、雌激素受体(ER)、核受体辅阻遏子(NCOR)及类固醇受体辅助活化因子-1(SRC-1)的表达及意义。方法应用免疫组织方法,检测并比较正常妇女外阴上皮组织、外阴营养不良上皮组织及外阴营养不良HIFU治疗后上皮组织中PR、ER、NCOR和SRC-1的阳性细胞平均光密度值(IOD)。结果 PR、ER、NCOR和SRC-1在外阴营养不良病变组织中的IOD值明显低于外阴正常上皮组织中的PR、ER、NCOR和SRC-1的IOD值(P<0.05);PR、ER、NCOR和SRC-1在外阴白斑病变治疗后的IOD值明显高于其在外阴白斑病变组织中的IOD值(P<0.05)。结论 PR、ER、NCOR和SRC-1在外阴营养不良病变组织中表达显著降低,这可能与外阴营养不良发病有关;HIFU治疗后,PR、ER、NCOR和SRC-1在外阴营养不良病变组织中的表达升高,可作为判断高强度聚焦超声疗效的指标。

Objective：To explore the expressions and significance of progesterone receptor（PR）,estrogen receptor（ER）,nuclear receptor corepressor（NCOR）,and steroid receptor coactivator-1（SRC-1） in epithelium of women with vulvar dystrophy treated by high-intensity focused ultrasound（HIFU）.Methods：Immunohistochemical method was used to detect and compare the mean integrated option density（IOD） of positive cells expressing PR,ER,NCOR,and SRC-1 in epithelium of women with normal vulva,vulvar dystrophy,and vulvar dystrophy after treatment by HIFU.Results：IOD values of PR,ER,NCOR,and SRC-1 in vulvar dystrophy tissue were statistically significantly lower than those in normal epithelium（P〈0.05）; IOD values of PR,ER,NCOR,and SRC-1 in vulvar dystrophy after treatment by HIFU were statistically significantly higher than those in vulval dystrophy（P〈0.05）.Conclusion：The expressions of PR,ER,NCOR,and SRC-1 in vulvar dystrophy decrease significantly,which may be correlated with the pathogenesis of vulvar dystrophy.After treated with HIFU,the expressions of PR,ER,NCOR,and SRC-1 in vulvar dystrophy increase,which can be used as indexes to predict the curative effect of HIFU.