108例碘帕醇不良反应文献分析

Analysis of 108 cases of adverse reactions of iopamidol from iteratures

目的:了解碘帕醇致不良反应(ADR)的情况,为临床合理用药提供参考。方法:采用文献学计量方法,对国内公开报道的108例碘帕醇ADR病例进行总结性分析。结果:碘帕醇致神经系统损害25例(23.15%);泌尿系统损害24例(20.37%);皮肤及其附件损害22例(20.37%);全身性损害15例(13.89%);消化系统损害13例(12.04%);血液系统损害5例(4.63%);循环系统损害4例(3.7%)。碘帕醇引起的不良反应症状位居前4位的分别为肾功能异常、头痛、胃肠道反应、脑缺血和过敏性休克等。结论:碘帕醇引起的不良反应应该引起临床重视。

OBJECTIVE To learn about the adverse drug reactions（ADR）induced by iopamidol and promote rational clinical drug use.METHODS By means of literature metrology method,108 cases of iopamidol ADR cases publicly reported in China are analyzed in summary.RESULTS There were 25 cases of nervous system damage caused by iopamidol（23.15%）;24 cases of urinary system damage（20.37%）;22 cases of injuries of skin and its appendages（20.37%）;15 cases of systemic damage（13.89%）;13 cases of digestive system damage（12.04%）;5 cases of blood system damage（4.63%）;4 cases of circulatory system damage（3.7%）.Symptoms of adverse reactions caused by complex among the top four were abnormal renal function,headache,gastrointestinal reactions such as anaphylactic shock,and cerebral ischemia.CONCLUSION Attention should be paid on adverse reactions induced by iopamidol.