药物代谢组学在肿瘤诊治中的应用与研究进展

Application and research progress of pharmaco-metabonomics in the diagnosis and treatment of tumor

随着代谢组学和现代分析技术、生物信息学技术的不断发展,药物代谢组学在肿瘤诊治方面的应用也日益成为研究热点,特别是在肿瘤药物疗效判断、毒性作用、耐药预测、个性化用药以及肿瘤标志物发现上有着重要作用。本文就药物代谢组学的概念、研究方法及其在肿瘤诊治中的应用等方面的研究进展进行综述。

With the development of metabonomics and modem instrumental analysis and bioinformatics, pharma- co.metahonomics has been rapidly put into the diagnosis and treatment of tumor, with a particularly important role in the evaluation and prediction of efficacy, toxicity and resistance of anti-tumor drugs, indivisualized medication and detection of tumor markers. This paper reviews the concept and methodologies of pharmaco-metabonomics, as well as the latest research advances of pharmaco-metabonomics in the diagnosis and freatment of tumors.