肺癌根治术淋巴结清扫对ⅢA期非小细胞肺癌的疗效

Efficacy of lung resection combined with lymphadenectomy for stage Ⅲ A non-small cell lung cancer

目的探讨肺癌根治术联合淋巴结清扫对ⅢA期非小细胞肺癌的临床疗效。方法将30例ⅢA期非小细胞肺癌患者随机分为两组，每组15例。研究组给予肺癌根治术联合系统淋巴结清扫术治疗；对照组给予传统肺癌根治术联合淋巴结清扫术治疗。记录并分析两组ⅢA期非小细胞肺癌患者近期疗效、并发症发生率、随访情况。结果研究组临床治疗总有效率为86．67％，对照组为80．00％（P〉0．05）；研究组术后并发症发生率为33．33％，对照组为40．00％（P〉0．05）；5年有效随访可知，研究组复发或转移率为46．67％，病死率为20．00％，均显著低于对照组复发或转移率（80．00％）和病死率（53．33％），差异有统计学意义（P〈0．05）。结论ⅢA期非小细胞肺癌患者经肺癌根治术治疗过程中联合给予系统淋巴结清扫术可显著提高其临床疗效及预后，有效降低患者病死率，保障其生活质量及生命安全。

Objective To investigate the clinical efficacy of the lung resection combined with lymphadenectomy. Methods Thirty patients with stage ⅢA non-small cell lung cancer were randomly divided into two groups, with 15 cases in each group. Study group received radical resection of lung cancer lymph node dissection for the treatment of joint system; the control group received conventional lung resection combined with lymphadenectomy treatment. The short-term efficacy of lung cancer patients with stage IliA non-small cell, the complication rate, follow-up cases between the two groups were recor- ded and analyzed. Results The clinical total effective rate of study group was 86. 67%, and 80. 00% in the control group （ P 〉 0. 05 ）. The postoperative complication rate of study group was 33.33%, and 40. 00% in the control group （P 〉 0. 05）. Five-year effective follow-up showed that the recurrence or me- tastasis rate was 46. 67% and the fatality rate was 20. 00% in study groups, which were significantly lower than those in the control group（80. 00% and 53.33% respectively, P 〈0. 05）. Conclusions Stage IliA non-small cell lung cancer patients after radical surgery during treatment administered in combination with lymph node dissection system can significantly improve the clinical efficacy and outcomes, reduce fatali- ty, guarantee quality of life and protect their lives and safety.