甲巯咪唑联合雷公藤多甙治疗甲亢患者的疗效及安全性研究

Study on effect and safety of methimazole combined with tripterygium glycosides in treatment of hyperthyreo-

目的探讨分析甲巯咪唑联合雷公藤多甙治疗甲状腺功能亢进症（以下简称甲亢）患者的疗效及安全性。方法回顾性分析2010年5月至2014年4月潢川县人民医院接治的84例甲亢患者的临床记录资料。结果治疗后，治疗组总有效率为90．48％，高于对照组的69．05％，差异有统计学意义（P〈0．05）；治疗后治疗组的血清游离三碘甲状腺氨酸（FT3）、血清游离甲状腺素（FT4）水平明显少于对照组，促甲状腺激素（TSH）水平明显高于对照组，超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）水平高于对照组，血浆骨钙素（BGP）、碱性磷酸酶（AKP）水平低于对照组，差异均有统计学意义（P〈0．05）。治疗组的不良反应发生率虽略高于对照，但差异未见统计学意义（P〉0．05）；治疗组的复发率低于对照组，差异有统计学意义（P〈0．05）。结论甲巯咪唑联合雷公藤多甙治疗甲亢患者的疗效显著，不良反应少，具有临床推广价值。

Objective To investigate the clinical effect and safety of methimazole combined with tripterygium gly- cosides in treatment of hyperthyreosis. Methods The clinical data of 84 patients with hyperthyreosis in the people＇ s hos- pital of Huangchuan from May 2010 to April 2014 were retrospectively analyzed. Results After treatment, the total effec- tive rate of the treatment group （90. 48% ） was higher than that of the control group（69.05% ）, there was significant difference （ P 〈 0. 05 ）. The FT3, FT4 levels of treatment group were significantly less than those of the control group after treatment; TSH level was significantly higher than that of the control group; SOD, GSH-Px levels were higher; BGP and AKP level were lower; all the differences above were significant （ P 〈 0.05 ）. The incidence of adverse reactions of treat- ment group was slightly higher than that of the control group, but there was no significant difference （P 〉 0.05 ）. The re- currence rate of the treatment group was significantly higher than that of the control group （ P 〈 0. 05 ）. Conclusions The mcthimazole combined with tripterygium glycosides in treatment of hyperthyreosis has excellent outcomes and few adverse reactions, so is worth clinical application.