武汉地区34家医院2011-2013年抗高血压药应用分析

Analysis of the Application of Antihypertensive Drugs in 34 Hospitals of Wuhan City during 2011 to 2013

目的:为临床合理用药和科学管理提供参考。方法:采用世界卫生组织推荐的限定日剂量为指标的分析方法,对武汉地区34家医院2011-2013抗高血压药有关数据进行统计、分析。结果:武汉地区2011-2013年抗高血压药销售金额和用药频度逐年增加,钙通道阻滞药(CCB)的销售金额和用药频度最高,构成比均达到40%左右,其次是血管紧张素Ⅱ受体拮抗药(ARB)和血管紧张素转换酶抑制剂(ACEI),新型复方制剂的销售金额和用药频度也明显增加。单药品种销售金额排名前3位的分别是氨氯地平、左旋氨氯地平和缬沙坦,用药频度居于前3位的是氨氯地平、硝苯地平和非洛地平。结论:武汉地区CCB、ARB、ACEI、肾上腺素受体阻滞药和利尿药最常用,符合目前抗高血压用药原则,临床应用基本合理。

OBJECTIVE： To provide reference for rational clinical use of drugs and sound management thereof. METH- ODS： The relative data of antihypertensive drugs applied in 34 hospitals in Wuhan city during 2011 and 2013 were analyzed sta- tistically by using the analytical method of the Defined Daily Dose （DDD） recommended by WHO. RESULTS： Both consump- tion amount and DDDs of antihypertensive drugs in Wuhan city were increasing during 2011 and 2013, where calcium-channel blockers （CCB） enjoyed the largest consumption amount and the highest DDDs, with the constituent ratio of over 40% respec- tively, followed by angiotensin 11 receptor antagonist （ARB） and angiotensin converting enzyme inhibitors （ACEIs）. The con- sumption amount and DDDs of new compound preparation also increased. Top three single drugs in terms of consumption amount were amlodipine, levamlodipine and valsartan, while amlodipine, nifedipine and felodipine ranked the top three in DDDs list. CONCLUSIONS： Wide usage of antihypertensive drugs in Wuhan City are respectively CCB, ARB, ACEI, adrener- gic receptor blockers and diuretics, which are applied in current principle of antihypertensive drugs use and basically rational in clinical application.