三七生肌膏预防皮瓣坏死的临床观察

Clinical Observation of Sanqi Shengji Ointment Preventing Skin Flap Necrosis

目的:观察三七生肌膏预防皮瓣坏死的临床效果。方法:将75例行头面部局部皮瓣转移修复术的患者按随机数字表法分为空白组、治疗组、对照组,各25例。空白组患者术后常规碘伏换药,治疗组患者术后在常规处理基础上应用三七生肌膏外敷,对照组患者术后在常规处理基础上应用外用重组人碱性成纤维细胞生长因子外敷,直至痊愈拆线。观察并比较3组患者术后皮瓣坏死情况、愈合等级、局部皮温、肿胀消失时间及创面愈合时间。结果:与空白组比较,治疗组与对照组患者术后皮瓣坏死率明显降低,差异有统计学意义(P<0.05);3组患者Ⅰ期愈合率比较,差异有统计学意义(P<0.05);3组患者术后皮瓣局部皮温比较差异无统计学意义(P>0.05);治疗组术后皮瓣肿胀消失时间与创面愈合时间明显短于对照组与空白组,差异有统计学意义(P<0.05)。结论:三七生肌膏对皮瓣转移修复术后的皮瓣坏死有确切的预防作用,与外用重组人碱性成纤维细胞生长因子的效果无明显差异,且在改善局部肿胀、缩短创面愈合时间方面优于该药。

OBJECTIVE： To observe the clinical effects of Sanqi shengji ointment （SQSJO） preventing skin flap necrosis. METHODS： 75 cases of local flap transfer in head and facial operation were randomly divided into blank group, treatment group, control group and with 25 cases in each group. After surgery, except for conventional treatment, treatment group was coated with SQSJO additionally; control group was additionally treated with rh-bFGF. The dressing was changed with iodophor in blank group conventionally till the wound healed. The skin flap necrosis, healing course, local skin temperature, swelling disappearance time and wound healing time were observed and compared among 3 groups after surgery. RESULTS： Compared with blank group, the incidence of skin flap necrosis decreased significantly in other 2 groups, there was statistical significance （P〈0.05）. There was sta- tistically significant difference in healing rate ameng 3 grups （P〈0.05） ; there was no statistical significance in local skin tempera- ture among 3 groups after surgery （P〉0.05） ; the flap swelling disappearance time and wound healing time of treatment group were significantly shorter than those of control group and blank group; there was statistical significance （P〈0.05）. CONCLU- SIONS： SQSJO can prevent skin flap necrosis accurately after flap transfer, and has no significant difference from rh-bFGF in pre- vention effect. Moreover, it is better than rh-bFGF in improving local swelling and shortening wound healing.