红景天治疗急性高原反应的临床观察

Clinical Observation of Rhodiola rosea in the Treatment of Acute Moutain Sickness

目的:观察红景天治疗急性高原反应(AMS)的疗效及安全性。方法:将首次从内地进藏的西藏大学新生中发生AMS的患者200例,按随机数字表法分为红景天组(67例)、银杏叶片组(65例)、乙酰唑胺组(68例)。每组受试者从进藏第1天开始服用对应药物,早晚各1次,连续服用7 d。观察并比较3组受试者在第1、3、5、7天的临床疗效以及不良反应发生情况。结果:3种药物治疗均对AMS有效。第1、3、5、7天红景天组的AMS症状评分均比银杏叶片组和乙酰唑胺组低,差异有统计学意义(P<0.05);第1、3天银杏叶片组的AMS症状评分比乙酰唑胺组低,差异有统计学意义(P<0.05),但第5、7天银杏叶片组的AMS症状评分与乙酰唑胺组比较差异无统计学意义(P>0.05)。第3、5、7天红景天组的血氧饱和度(Sa O2)高于银杏叶片组和乙酰唑胺组,第1、3、5、7天红景天组的心率(HR)低于银杏叶片组和乙酰唑胺组,差异均有统计学意义(P<0.05);但银杏叶片组和乙酰唑胺组的Sa O2及HR比较差异无统计学意义(P>0.05)。红景天组未发生任何不良反应。结论:红景天可以减轻缺氧症状的严重程度,用于治疗AMS临床疗效确切、治愈时间短、安全性好。

OBJECTIVE： To observe therapeutic efficacy and safety of Rhodiola rosea in the treatment of acute mountain sick- ness （AMS）. METHODS： 200 students with AMS in Tibet university from main land China, who had never been at high altitude before, were randomly divided into 3 groups by humber： R. rosea group （67 patients）, Ginkgo biloba group （65 patients） and ac- etazolamide group （68 patients）. Each group was given relevant medicine on the first day of inbound Tibet, morning and night, for consecutive 7 days. Clinical efficacy and ADR of 3 groups were observed and compared on first, third, fifth and seventh day. RE- SULTS： 3 kinds of drugs were effective for AMS. On first, third, fifth and seventh day, AMS sore of R.rosea group was lower- than other 2 groups, there was statistically significant difference （P〈0.05） ; On first and third day, AMS score of G.biloba group was lower than that of acetazolamide group, there was statistically significant difference （P〈0.05）, while there was no statistically significant difference between 2 groups on fifth and seveth day （P〉0.05）. On third, fitLh and seventh day, the oxygen saturation （SaOz） ofR. rosea group were higher than other 2 groups; while, heart rate （HR） was lower than other 2 groups, there was statis- tical significance （P〈0.05） ; SaO2 and HR of G.biloba group and acetazolamide group had no statistically significant difference （P〉0.05）. No ADR was found in R. rosea group. CONCLUSIONS： R. rosea can reduce the severity of hypoxia, and it have good treatment effect on AMS, short cure time and good security.