稳消方对颈动脉粥样硬化不稳定斑块MCP-1、VCAM-1表达、脂质代谢、踝臂指数的影响

Effect of Wenxiao decoction on the expression of MCP-1 and VCAM-1,lipids metabolism and ankle brachial index in carotid atherosclerotic instable plaque

目的观察稳消方对颈动脉粥样硬化不稳定斑块炎症因子、脂质代谢、踝臂指数的影响。方法将78例动脉粥样硬化患者随机分为2组,每组39例。对照组给予基础治疗,干预组在基础治疗同时加用稳消方。2组疗程均为24周,观察治疗前后人血清单核细胞趋化蛋白-1(MCP-1)、血管细胞黏附因子-1(VCAM-1)、血脂水平及踝臂指数变化。结果最终完成研究69例,对照组36例,干预组33例。2组治疗后MCP-1、VCAM-1、血脂水平及踝臂指数均较治疗前明显改善(P均<0.05),且干预组各指标改善情况均明显优于对照组(P<0.05)。结论稳消方可抑制炎症因子表达,改善脂质代谢,降低踝臂指数,从而达到延缓动脉硬化、减少斑块的目的。

Objective It is to observe the effect of Wenxiao decoction on inflammatory factors, lipid metabolism and ankle brachial index in carotid atherosclerosis instable plaque. Methods 78 patients with carotid atherosclerosis instable plaque were randomly divided into 2 groups, each group had 39 cases. The control group were given basic treatment while the intervention group was added with Wenxiao decoction on the basis of basic therapy. Both the treatment courses were 24 weeks. The changes of human serum monoeyte ehemoattraetant protein - 1 （ MCP - 1 ） , vascular cell adhesion molecule - 1 （ VCAM - 1 ） , blood lipid, ankle brachial index were observed before and after treatment. Results There were 69 patients included in the per protocol set （PPS） ultimately, 36 cases in the control group and 33 cases in the intervention group. After treatment, the levels of MCP -1,VCAM -1, blood lipid and ankle braehial index were significantly improved compared with that before treatment（P 〈 0.05） , and the improvements in the＇intervention group were more significantly than that in the control group （ P 〈 0.05 ）. Conclusion Wenxiao decoction could inhibit the expression of inflammatory factors, improve lipid metabolism, reduce the ankle brachial index, thus to postpone arteriosclerosis and then reduce plaque.