补阳还五汤治疗脑卒中后抑郁的疗效和安全性系统评价

T he Systematic Review of the Effects and Safty of Buyang Huanwu Tang on Post-Stroke Depression

目的系统评价补阳还五汤治疗脑卒中后抑郁的有效性和安全性。方法纳入以脑卒中后抑郁患者为研究对象,比较补阳还五汤与西药治疗效果的随机对照试验,评价纳入研究的质量,并用Rev Man5.3软件进行Meta分析。结果补阳还五汤治疗脑卒中后抑郁患者总体疗效优于西药治疗,其汇总OR=2.24,95%CI[1.19,4.18],差异有统计学意义(P<0.05);在改善汉密顿抑郁量表评分方面,补阳还五汤的效果较西药没有差异,汇总MD=0.00,95%CI[-0.97,0.98];安全性方面,补阳还五汤治疗脑卒中后抑郁发生明显不良反应低于西药治疗OR=0.07,95%CI[0.01,0.58],差异有统计学意义(P<0.05)。结论补阳还五汤治疗脑卒中后抑郁在总体疗效和安全性方面显示出比西药治疗更加有效的倾向,尚需更多高质量研究以增加证据的强度。

Objective： To systematically evaluate the effects and safety of Buyang Huanwu Tang on post-stroke depression. Methods： Patients with post-stroke depression were identified as the research object. Randomized controlled trials were used to compare the effects of Buyang Huanwu Tang with that of western therapeutic.The e- valuation was included in the quality of studies with Meta analysis of RevMan5.3 software. Results： The overall efficacy of Buyang Huanwu Tang on patients with post-stroke depression was superior to western medicine treat- ment,with its summary OR=2.24,95%CI [1.19,4.18]. The difference was statistically significant （P〈 0.05）. Buyang Huanwu Tang in improving the HAMD scores had the same efficacy as western medicine treatment,with its summary MD=0.00,95%CI [0.01,0.58 ]. For the security aspects, adverse reactions of Buyang Huanwu Tang on post-stroke depression were significantly lower than that of western medicine, with its summary OR=0.07,95%CI [ 0.01,0.58]. The difference was statistically signifieant （P〈 0.05）. Conclusion： Buyang Huanwu Tang is more ef- fective than Western medicine with a tendency in the overall efficacy and safety, but still needs more high-quality research to strengthen this evidence.