自拟中药联合西药治疗早发型重度子痫前期的临床观察被引量：9

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摘要目的观察自拟中药联合西药治疗早发型重度子痫前期的临床效果,并初步探讨其免疫调节作用。方法将早发型重度子痫前期孕妇79例随机分为治疗组40例和对照组39例,两组均采用西医常规治疗,治疗组加服自拟中药汤剂,另选择同期正常晚期妊娠孕妇40例作为正常组。比较治疗组和对照组治疗前后平均动脉压、24 h尿蛋白定量、胎儿脐动脉S/D值及对妊娠并发症、妊娠结局影响的差异;采用酶联免疫双抗体夹心法检测各组孕妇血清肿瘤坏死因子-γ(IFN-γ)、白细胞介素-10(IL-10)水平并计算IFN-γ/IL-10比值,进行分析。结果治疗组治疗后平均动脉压、24 h尿蛋白定量较对照组下降更明显(P<0.05),治疗组胎儿窘迫及胎儿生长受限发生率低于对照组(P<0.05)。治疗组孕周延长时间长于对照组,新生儿出生体质量高于治疗对照组(P<0.05)。治疗前治疗组和对照组血清中IFN-γ水平较正常对照组均增高,IL-10水平均降低,IFN-γ/IL-10比值均增高(P<0.05)。治疗后,治疗组和对照组与本组治疗前比较,血清IFN-γ水平均降低,血清IL-10水平均升高,血清IFN-γ/IL-10比值均降低,差异均有统计学意义(P<0.05)。结论自拟中药联合西药治疗早发型重度子痫前期疗效显著,其作用机制可能是通过调节机体的Th1/Th2免疫平衡而实现的。

作者郭瑞新胥文萍刘以欣

机构地区山东省潍坊市中医院

出处《中国中医急症》 2015年第7期1283-1285,1313,共4页 Journal of Emergency in Traditional Chinese Medicine

关键词早发型重度子痫前期中西医结合免疫学

分类号 R714.245 [医药卫生—妇产科学]

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