祛痰化瘀方药对心血管疾病中内皮细胞保护作用的研究评述

Overview on the protective effects of phlegm-blood stasis formula on vascular endothelial cells in cardiovascular diseases

痰瘀互结是心血管疾病的重要病因病机,治疗上宜痰瘀同治。内皮细胞具有屏障、血管调节、分泌细胞因子及免疫调节等多种功能,其形态及功能改变在心血管疾病痰瘀互结证发展过程中具有重要作用。目前研究发现,祛痰化瘀药物多用全瓜蒌、薤白、半夏、陈皮、川芎等,其作用主要集中在影响内皮细胞增殖、凋亡,以及调节内皮细胞分泌活性物质如一氧化氮、内皮素、血管内皮生长因子、白介素等方面。本文试从祛痰化瘀方药对高脂血症与动脉粥样硬化、高血压及冠心病等常见心血管疾病中内皮细胞的保护作用做一综述。

Intermingled phlegm-blood stasis is the important etiology and pathogenesis of cardiovascular diseases. The diagnosing principle should be treating both phlegm and blood stasis. The vascular endothelial cells（ VECs） have a variety of functions,such as protection and regulation of blood vessels,secretion of cytokines and regulation of immunity. Therefore,the morphological and functional changes of VECs play an important role in the development of phlegm-blood stasis syndrome in cardiovascular diseases. Recent studies showed that herbs like snakegourd fruit,allium macrostemon,pinellia,dried orangepeel,ligusticum,and wallichii,which are main herbs of phlegm-resolving and stasis-dispelling formula,affected endothelial cell proliferation,apoptosis,and regulation of secreting bioactive substances of endothelial cells such as NO,ET,VEGF,interleukin,etc. This study reviewed the protection of the phlegmblood stasis formula on endothelial cells in cardiovascular diseases caused by hyperlipidemia,atherosclerosis,hypertension and coronary heart diseases.