脑钠肽对老年患者腹部手术后主要心血管事件的预测价值

Predictive value of brain natriuretic peptide for main adverse cardiovascular events in elderly patients undergoing abdominal surgery

目的探讨血浆脑钠肽(brain natriuretic peptide,BNP)浓度对老年患者腹部手术后主要心血管事件发生风险的预测价值。方法选择广东省广宁县人民医院普外科住院拟行腹部手术的患者135例,根据术前血浆BNP浓度分为高BNP组(BNP≥100 pg/m L,n=58)及正常BNP组(BNP<100 pg/m L,n=77)。对比分析两种术后主要心血管事件的发生情况。结果术前高BNP组血浆BNP浓度明显高于对照组,差异有统计学意义[(127.5±12.3)pg/m L vs.(63.1±10.4)pg/m L,P<0.05]。术后高BNP组主要心血管事件发生率明显高于对照组,差异有统计学意义[20.7%(12/58)vs.1.3%(1/77),P<0.05]。结论术前BNP检测有助于预测老年患者腹部手术后主要心血管事件发生风险。

Objectives To observe the value of plasma brain natriuretic peptide（BNP） in predicting perioperative main adverse cardiovascular events in elderly patients undergoing abdominal surgery. Methods Totally 135 patients undergoing abdominal surgery in People＇s Hospital of Guangning County were divided into high BNP group（BNP≥100 pg / m L,n =58） and normal BNP group（BNP〈100 pg / m L, n =77） according to the plasma concentration of BNP. Incidence of main adverse cardiovascular events between the two groups was estimated and compared. Results Plasma concentration of BNP in high BNP group was significantly higher than that in normal BNP group before surgery [（127.5 ±12.3） pg / m L vs.（63.1 ±10.4） pg / m L, P〈0.05 ]. Incidence of main adverse cardiovascular events in high BNP group was obviously higher than that in normal BNP group after surgery [20.7%（12 / 58） vs. 1.3%（1 / 77）, P0.05]. Conclusions Detection of preoperative BNP concentration is useful to predict the main adverse cardiovascular events in elderly patients undergoing abdominal surgery.