TORCH病原体感染与自然流产的关系及影响因素

The relationship between TORCH infections and natural abortion and its influence factors

目的探讨TORCH病原体感染与自然流产的相关性,分析其可能的影响因素。方法对2012年9月至2014年9月于四川省人民医院就诊的831例妇女采用化学发光法进行TORCH-Ig M及Ig G四项检测,将363例有自然流产史的妇女纳入A组,468例无自然流产史妇女纳入B组,比较两组TORCH感染阳性率及影响因素。结果 A组妇女HSV-Ig G(64.4%)、CMV-Ig M(5.0%)Tox-Ig M(5.8%)及HSVIg M(9.1%)抗体的阳性率均高于B组(分别为57.1%、1.9%、2.6%、5.6%)(P<0.05)。在A组中,农村妇女巨细胞病毒(cytomegalovirus,CMV)、弓形虫(toxoplasma,Tox)、风疹病毒(rubella virus,RV)、生殖器单纯疱疹病毒(herpes simplex virus,HSV)病原体的感染率分别为7.1%、7.6%、7.6%、12.1%均高于城市(2.4%、1.8%、3.6%、4.4%)(P<0.05);有动物接触史的妇女TORCH检出率高于无动物接触史的妇女(P<0.05)。结论 TORCH病原体感染与自然流产密切相关,农村、有动物接触史为TORCH感染的高危因素。

Objective To investigate the correlation between TORCH infections and natural abortion, to analyze the potential influence factors. Methods A total of 831 women were detected by chemiluminescence method in Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇ s Hospital from Sept. 2012 to Sept. 2014, 363 women with natural abortion history were selected into group A and 468 women without natural abortion history were divided into group B, the positive rates of TORCH and influence factors were compared. Results The positive rates of HSV - IgG, CMV - IgM, Tox - IgM and HSV - IgM in group A [64. 4 % ,5.0 %, 5.8 % ,9. 1% respectively]were higher than that in group B（57.1% ,1.9 % ,2. 6 % ,5.6 % respectively） （P 〈0. 05）. In group A, infections of cytomegalovirus （CMV）, toxoplasma （Tox） and herpes simplex virus （HSV） of the women in rural [ 7.1% ,7.6 % , 7. 6 % ,12. 1% respectively ] were higher than that in urban [ 2.4 %, 1.8 % ,3.6 % ,4. 4 % respectively ] （ P 〈 0.05 ）. TORCH positive rate of women who have history of exposure to animals was higher than that without history of exposure to animals（ P 〈0. 05 ）. Conclusion TORCH pathogens infection was related with natural abortion, rural area, and history of exposure to animals were high risk factors of TORCH infections.