通络平嗽汤联合孟鲁司特钠及硫酸沙丁胺醇气雾剂在咳嗽变异性哮喘患儿中的疗效研究

Tongluo Pingchuan Decoction Combined Montelukast Soudium Tablets and Salbutamol Sulphate Aerosol in Treatment of Children with Cough Variant Asthma

目的:研究通络平嗽汤联合孟鲁司特钠及硫酸沙丁胺醇气雾剂在咳嗽变异性哮喘患儿中的疗效。方法:选择2013年1月—2014年1月的患儿100例,将患者随机分为观察组和对照组,各50例。对照组采用孟鲁司特钠及硫酸沙丁胺醇气雾剂治疗,观察组采用通络平嗽汤联合孟鲁司特钠及硫酸沙丁胺醇气雾剂治疗。治疗前后分别测定两组患儿的肺功能改善情况,并在治疗后将两组患儿的复发情况分析对比。结果:治疗组的咳嗽缓解时间、咳嗽消失时间均明显低于对照组,差异具有统计学意义(P<0.05);两组之间的复发率差异无统计学意义(P>0.05)。两组患儿治疗后的FVC、FEV1、FEV1.0、PEF与治疗前差异显效,具有统计学意义(P<0.05)。所有患儿在接受治疗方案规定的治疗剂量和疗程中未出现严重不良反应,两组之间安全性比较无显著性差异(P>0.05)。结论:通络平嗽汤联合孟鲁司特钠及硫酸沙丁胺醇气雾剂在咳嗽变异性哮喘患儿中的效果显著,且安全可靠,可以在临床上推广使用。

Objective：To study the effect of Tongluo Pingchuan Decoction combined Montelukast Soudium Tablets and salbutamol sulfate aerosol in the children with cough variant asthma. Methods：Between January 2013 to January 2014 in our hospital, 100 cases were randomly divided into observation group and control group,50 cases in each. Control group a- dopted Montelukast Soudium Tablets and salbutamol sulfate aerosol therapy and observation group used Tongluo Ping- chuan Decoction combined Montelukast Soudium Tablets and salbutamol sulfate aerosol. Before and after treatment, two groups pulmonary function improvement and recurrent situation were compared. Results：Treatment group＇s cough cough re- lief time and disappear time were significantly lower than those of the control group and the difference was statistically sig- nificant （P 〈 0. 05 ）. There was no statistically significant difference of recurrence rates between two groups （ P 〉 0.05 ）. After treatment, two groups＇s FVC, FEV1, FEV1.0 and PEF were statistically significant compared with those before treat- ment （ P 〈 0.05 ）. All children within the treatment scheme did not appear serious adverse reactions and the security had no significant difference between two groups （ P 〈 0.05 ）. Conclusion ： Tongluo Pingchuan Decoction combined Monte- lukast Soudium Tablets and salbutamol sulfate aerosol in the children with cough variant asthma has remarkable effect and it is safe and reliable and can be used in clinic.