2型糖尿病肥胖患者血清铁蛋白与胰岛素抵抗关系的研究

Relationship between the levels of serum ferritin and insulin resistance in obese patients with type 2 diabetes

目的观察肥胖T2DM患者血清铁蛋白(SF)水平与IR的关系。方法选取T2DM患者100例,根据BMI分为糖尿病合并肥胖组(DM+Ob,BMI≥28kg/m2)54例和单纯糖尿病(DM,BMI<28kg/m2)组46例。另选取同期正常体检者50名作为对照(NC)组。检测各组SF、FPG、FIns、TC、TG及HbA1c水平,并计算胰岛素抵抗指数(HOMA-IR)。观察SF水平和HOMA-IR的变化,分析两者的相关性。结果 DM+Ob组SF[(292.66±88.53)vs(167.52±67.04)vs(152.17±50.12)ng/ml]及HOMA-IR[(4.20±1.61)vs(1.87±0.97),(1.73±0.86)]均高于DM组和NC组(P<0.05)。Pearson相关分析显示,SF与HOMA-IR呈正相关(r=0.79,P<0.05)。多元逐步回归分析显示,SF与SBP、HbA1c、BMI、HOMA-IR呈正相关(P<0.05)。结论 T2DM肥胖患者SF、HOMA-IR水平高于单纯T2DM患者,SF与HOMA-IR呈正相关。

Objective To investigate the relationship between the levels of serum ferritin（SF）and insulin resistance in obese patients with type 2diabetes（T2DM）. Methods 100T2 DM patients were divided into two groups based on BMI：T2DM with obesity（DM＋Ob group,BMI≥28kg/m2,n=54）and T2 DM without obesity（DM group,BMI28kg/m2,n=46）,50 cases of healthy people were selected as normal control（NC group）.The levels of SF,FPG,FIns,TC,TG,and HbA1 c were measured.Insulin resistance index（HOMA-IR）was calculated by the formula. Results Both SF [（292.66±88.53）vs（167.52±67.04）vs（152.17±50.12）ng/ml]and HOMA-IR [（4.20±1.61）vs（1.87±0.97）,（1.73±0.86）]in DM＋Ob group were higher than in DM and NC group（all P〈0.05）.Pearson correlation analysis showed that SF was positively correlated with HOMA-IR（r=0.79,P〈0.05）.Multiple regression analysis suggested that SF was correlated with SBP,HbA1 c,BMI and HOMA-IR（P〈0.05）.Conclusion The levels of SF and HOMA-IR in obese type 2diabetic patients is higher.There is a linear relationship between SF and HOMA-IR.