糖尿病周围神经病变患者颈动脉内-中膜厚度、颈动脉僵硬度与糖化血红蛋白的相关性研究

Relationship between HbA_1c and CIMT,carotid arterial stiffness of diabetic peripheral neuropathy patients

目的探讨DPN患者颈动脉内-中膜厚度(CIMT)、颈动脉僵硬度与HbA1c的关系。方法选取T2DM组60例、DPN组100例及健康体检者(NC)60名,测定HbA1c水平、CIMT和颈动脉僵硬度。结果 DPN组HbA1c[(8.62±2.71)%vs(4.20±0.47)%,(7.59±1.98)%],CIMT[(1.01±0.11)vs(0.70±0.07),(0.81±0.09)mm]和颈动脉硬度[(827.6±123.7)vs(521.2±89.3),(629.3±113.5)]高于NC、T2DM组(P<0.05);DPN组病程高于T2DM组(P<0.05);DPN组HbA1c≥10.0%亚组CIMT[(1.11±0.09)vs(0.94±0.07),(0.73±0.06)mm]和颈动脉僵硬度[(901.5±241.5)vs(724.5±159.9),(574.1±145.3)]高于8.0%≤HbA1c<10.0%亚组和7.0%≤HbA1c<8.0%亚组(P<0.05);相关分析结果显示,HbA1c与CIMT、颈动脉僵硬度呈正相关(r=0.107、0.213,P<0.05)。结论 DPN患者CIMT、颈动脉僵硬度与HbA1c呈正相关,且HbA1c是CIMT和颈动脉僵硬度的危险因素。

Objective To explore the relationship between HbA1 c and carotid artery intima-media thickness（CIMT）,carotid arterial stiffness in diabetic patients with peripheral neuropathy. Methods A total of 220 subjects were enrolled in this study and divided into three groups：T2DM group（n=60）,DPN group（n=100）,and healthy individuals as NC group（n=60）.Serum HbA1 c,CIMT and carotid arterial stiffness were measured. Results HbA1 c [（8.62±2.71）% ],CIMT [（1.01±0.11）mm]and carotid arterial stiffness[（827.6±123.7）]was significantly higher in DPN group than in NC group [（4.20±0.47）%,（0.70±0.07）mm,（521.2±89.3）]and T2 DM group [（7.95±1.98）%,（0.81±0.09）mm,（629.3±113.5）]respectively（P〈0.05）.The duration was significantly longer in DPN group than in T2 DM group（P〈0.05）.CIMT [（1.11 ± 0.09）mm]and arotid arterial stiffness[（901.5 ± 241.5）]was higher in patients with HbA1c≥10.0%than in patients with HbA1 c between 8.0%~10.0% [（0.94±0.07）mm,（724.5±159.9）]and patients with HbA1 c between 7.0% ~8.0% [（0.73±0.06）mm,（574.1±145.3）]respectively（P〈0.05）.Association analysis showed that HbA1 c had a positive correlation with CIMT and carotid arterial stiffness（r=0.107,0.213,P〈0.05）. Conclusion CIMT and carotid stiffness are positively correlated with HbA1 c in DPN patients.HbA1 c is a risk factor for CIMT and carotid stiffness.