摘要
DPN的发生发展是复杂的、多种致病因素共同作用的结果,氧化应激(OS)和炎症在其中发挥重要作用。血红素加氧酶-1(HO-1)及其降解产物具有抗氧化、抗炎、抗凋亡、促血管生成等多种功效,可作为DPN防治研究的新靶点。
The pathogenesis of diabetic peripheral neuropathy（DPN）is the result of complex multiple concurrent pathogenic factors,among which oxidative stress and inflammation play important roles.Multiple data have indicated that haem oxygenase-1（HO-1）and its degradation products products possess the functions of anti-oxidation,anti-inflammation,anti-apoptosis and pro-angiogenesis,which now becomes a new target for the treatment of DPN.We will briefly review the progression on the research of HO-1and DPN.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2015年第7期653-656,共4页
Chinese Journal of Diabetes
基金
国家自然科学基金(81001580)
关键词
糖尿病周围神经病变
氧化应激
炎症
血红素加氧酶-1
Diabetic peripheral neuropathy（DPN）
Oxidative stress（OS）
Inflammation
Haem oxygenase-1（HO-1）
