窄谱中波紫外线联合枸地氯雷他定及润燥止痒胶囊治疗老年糖尿病性瘙痒症疗效观察

Clinical observation of narrow-band ultraviolet B combined with desloratadine citrate disodium and Runzao Zhiyang Capsule on patients with senile diabetic pruritus

目的观察窄谱中波紫外线(NB-UVB)联合枸地氯雷他定和润燥止痒胶囊治疗老年糖尿病性瘙痒症的效果及其安全性。方法将75例老年糖尿病性瘙痒症患者随机分成治疗组38例和对照组37例,2组均给予枸地氯雷他定和润燥止痒胶囊口服,治疗组加用NB-UVB全身照射。治疗4周后,观察比较2组瘙痒程度、发作频率、持续时间、对睡眠影响程度、症状总积分、临床疗效、复发率和不良反应情况。结果治疗4周后2组的瘙痒程度、发作频率、持续时间、对睡眠影响程度、症状总积分显著低于治疗前(P均<0.05),且治疗组治疗后各项评分及症状总积分均明显低于对照组(P均<0.05)。而治疗4周后治疗组的有效率为95%,对照组为76%,2组比较差异有统计学意义(P<0.05)。停药后8周,治疗组的复发率为10%,对照组为36%,2组复发率比较差异有统计学意义(P<0.05);2组不良反应情况比较差异无统计学意义。结论 NB-UVB联合枸地氯雷他定、润燥止痒胶囊治疗老年糖尿病性瘙痒症具有疗效高、复发率低、安全可靠等优点,值得临床推广应用。

Objective It is to observe the clinical efficacy and safety of narrow-band ultraviolet B combined with deslorata- dine citrate disodium （DCD） and Runzao Zhiyang capsule （RZC） on patients with senile diabetic pruritus. Methods 75 patients were randomly divided into treatment group and control group; both groups were given DCD and RZC for oral, the treatment group was added with NB - UVB whole body irradiation. After 4 weeks of treatment, the degree of itching, seizure fre- quency, duration, effects on sleep, total symptom integral, clinical efficacy, recurrence rate and adverse reaction of the two groups were observed and compared. Results After the treatment, the degree of itching, seizure frequency, duration, effects on sleep, total symptom integral of the treatment group were significantly lower than that of the control group （all P 〈 0.05）. After 4 weeks of treatment, the effective rate was 95% in the treatment group and was 76% in the control group, there was sig- nificant difference between the both groups（P 〈 0.05）. After 8 weeks of treatment, the recurrence rate was 10% in the treat- ment group and was 36% in the control group, there was significant difference between the both groups （P 〈 0. 05 ）. There was no significant difference in adverse reaction between the both groups. Conclusion The curative effect of NB - UVB combined with DCD and RZC on patients with senile diabetic pruritus is better with high efficacy and low recurrence rate, it is safe and reliable.