血浆铁蛋白、铁代谢基因与冠心病的相关性分析

Correlation analysis of plasma ferritin,iron metabolism genes and coronary heart disease

目的:分析总结冠心病与血浆铁蛋白(FT)及铁代谢基因(HFE)的相关性。方法:以30例健康者为对照组,以30例稳定性心绞痛(SAP)患者为SAP组,以30例患不稳定心绞痛(UA)患者为UA组,以30例急性心肌梗塞(AMI)患者为AMI组。分析4组患者间FT含量及HFE阳性表达率的差异,并对各组患者的FT含量及HFE阳性表达率与冠心病相关性进行分析。结果:4组研究对象间,AMI组患者的FT含量最高(P<0.05);4组研究对象间HFE阳性表达率比较无统计学差异(P>0.05);FT含量与冠心病存在相关性(P<0.05),HFE阳性表达率与冠心病无相关性(P>0.05)。结论:FT含量与冠心病存在相关性。

Objective： To analyze and summarize correlations of coronary heart disease,plasma ferritin（ FT） and iron metabolism gene（ HFE）. Methods： 30 healthy people were as control group,30 patients with stable angina pectoris were as SAP group,30 patients with unstable angina pectoris were as UA group,and 30 patients with acute myocardial infarction were as AMI group. The differences of the FT content and HFE positive expression rate among the four groups were analyzed. The correlations of the FT content,HFE positive expression rate and coronary artery disease in each group were analyzed. Results： Among the four groups,AMI group had the highest FT content（ P〈0. 05）,and there were no statistical differences in the HFE positive expression rate（ P〉0.05）. The FT content and coronary heart disease had a significant correlation（ P〈0. 05）,but the HFE positive expression rate was not correlated with coronary heart disease（ P〉0. 05）. Conclusions： The FT content and coronary heart disease had a correlation.