利福平与利福喷汀抗结核治疗效果对比分析

Comparative Analysis of Rifampin and Rifapentine in Treatment of Tuberculosis

目的探讨利福平与利福喷汀用于治疗肺结核的疗效与不良反应的差异。方法选择我院收治的120例肺结核患者,随机分为观察组与对照组各60例,观察组给予包含利福喷汀的抗结核治疗,对照组给予包含利福平的抗结核治疗,比较两组患者的痰菌阴转率、空洞闭合率和病灶显著吸收率以及不良反应的发生情况。结果观察组在痰菌阴转率、空洞闭合率和病灶显著吸收率方面均优于对照组,差异均具有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论利福喷汀抗结核治疗疗效显著,而且不良反应较少,是肺结核患者较为理想的用药选择。

Objective To investigate the efficacy of rifampin and rifapentine used in the treatmeat of tuberculosis and incidence rate in adverse reactions. Methods 120 cases of pulmonary tuberculosis patients in our hospital were randomly divided into observation group and control group with 60 cases respectively. The observation group was given rifampin and the control group was given rifapentine. The sputum negative conversion rate, lesions absorption rate, chest focus absorptivity rate and the occurrence of adverse reactions were compared between the two groups. Results The rates of sputum negative conversion, lesions absorption and chest focus absorptivity were better than that in control group,while incidence of adverse reactions was lower than control group.The differences were statistically significant （P〈 0.05）. Conclusion Rifapentine has great activity against TB bacteria and less adverse reactions. Rifapentine is a superior drug for the treatment of TB.